Carrier-mediated transport of cephalexin via the dipeptide transport system in rat renal brush-border membrane vesicles.

@article{Inui1984CarriermediatedTO,
  title={Carrier-mediated transport of cephalexin via the dipeptide transport system in rat renal brush-border membrane vesicles.},
  author={Ken-ichi Inui and Teruo Okano and Mikihisa Takano and Hideyuki Saito and Ryohei Hori},
  journal={Biochimica et biophysica acta},
  year={1984},
  volume={769 2},
  pages={449-54}
}
Carrier-mediated transport of aminocephalosporin antibiotics by renal brush-border membrane vesicles has been studied in relation to the transport systems for dipeptides and amino acids. Dipeptides such as L-carnosine (beta-alanyl-L-histidine) and L-phenylalanylglycine competitively inhibited the uptake of cephalexin, but amino acids did not. Cephalexin uptake was stimulated by the countertransport effect of L-carnosine in the normal and papain-treated vesicles, and by the effect of L… CONTINUE READING

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