Carrier-mediated transport of cephalexin via the dipeptide transport system in rat renal brush-border membrane vesicles.

@article{Inui1984CarriermediatedTO,
  title={Carrier-mediated transport of cephalexin via the dipeptide transport system in rat renal brush-border membrane vesicles.},
  author={Ken-ichi Inui and T Okano and Mikihisa Takano and Hideyuki Saito and Ryohei Hori},
  journal={Biochimica et biophysica acta},
  year={1984},
  volume={769 2},
  pages={
          449-54
        }
}
  • K. Inui, T. Okano, +2 authors R. Hori
  • Published 25 January 1984
  • Chemistry, Medicine
  • Biochimica et biophysica acta
Carrier-mediated transport of aminocephalosporin antibiotics by renal brush-border membrane vesicles has been studied in relation to the transport systems for dipeptides and amino acids. Dipeptides such as L-carnosine (beta-alanyl-L-histidine) and L-phenylalanylglycine competitively inhibited the uptake of cephalexin, but amino acids did not. Cephalexin uptake was stimulated by the countertransport effect of L-carnosine in the normal and papain-treated vesicles, and by the effect of L… 
Characterization of the transport system for beta-lactam antibiotics and dipeptides in rat renal brush-border membrane vesicles by photoaffinity labeling.
TLDR
The data indicate that the transport systems for beta-lactam antibiotics and dipeptides in the brush-border membrane from rat kidney and small intestine are similar but not identical.
Carrier-mediated transport system for cephalexin in human placental brush-border membrane vesicles.
TLDR
The results indicate the existence of a carrier-mediated transport system for cephalexin in the human placental brush-border membranes.
H+ gradient-dependent transport of aminocephalosporins in rat intestinal brush-border membrane vesicles. Role of dipeptide transport system.
TLDR
The present data suggest that aminocephalosporins can be transported by a common carrier-mediated system with dipeptides in the intestinal brush-border membranes and this process may be driven by an H+ gradient.
Transport of bestatin in rat renal brush-border membrane vesicles
Abstract Bestatin [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl- l -leucine] is a dipeptide, comprising l -leucine and an unusual β-ammo acid. We studied its transport mechanism in rat renal
Interaction of b-Lactam Antibiotics with H 1 / Peptide Cotransporters in Rat Renal Brush-Border Membranes 1
Two H/peptide cotransporters, PEPT1 and PEPT2, are expressed in the kidney, mediating the renal tubular reabsorption of oligopeptides and b-lactam antibiotics. We examined the interactions of
Interaction of β-Lactam Antibiotics with H+/Peptide Cotransporters in Rat Renal Brush-Border Membranes
TLDR
It is concluded that amino-β-lactam antibiotics at therapeutic concentrations interact predominantly with PEPT2 localized in the brush-border membranes of rat kidney.
Inactivation of the intestinal uptake system for beta-lactam antibiotics by diethylpyrocarbonate.
TLDR
It is concluded that a specific interaction of the alpha-amino group in the substituent at position 6 or 7 of the penam or cephem nucleus presumably with a histidine residue of the transport protein is involved in the translocation process of orally active alpha- amino-beta-lactam antibiotics across the intestinal brush-border membrane.
Transport of cephalosporin antibiotics in rat renal basolateral membranes
TLDR
It is suggested that most cephalosporins are transported via organic anion transport systems in rat renal basolateral membranes through isolated membrane vesicles.
Transport of beta-lactam antibiotics in kidney brush border membrane. Determinants of their affinity for the oligopeptide/H+ symporter.
TLDR
The data suggest that: (a) the transport of aminocephalosporins is largely mediated by the oligopeptide/H+ symporter, which is highly influenced by the substrate structure; and (b) penicillins are transported by another system,which is less discriminative with respect to substrate structure.
Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesicles.
TLDR
The results suggest that tetraethylammonium transport across brush-border membranes is driven by an H+ gradient via an electroneutral H+-tetraethyammonium antiport system, and that this process is stimulated by an inside-negative membrane potential.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 13 REFERENCES
Carrier-mediated transport of amino-cephalosporins by brush border membrane vesicles isolated from rat kidney cortex.
TLDR
The present results suggest the existence of a carrier-mediated transport system for amino-cephalosporins in brush border membranes, which may be a part of the mechanism of tubular reabsorption of these antibiotics.
Evidence for a dipeptide transport system in renal brush border membranes from rabbit.
TLDR
It is demonstrated that renal brush border vesicles can efficiently handle dipeptides by a mechanism completely different from that of amino acid transport.
Characteristics of dipeptide transport in normal and papain-treated brush border membrane vesicles from mouse intestine. I. Uptake of glycyl-L-phenylalanine.
TLDR
A linear relationship has been established between initial dipeptide uptake and glycyl-L-phenylalanine concentration for the intact peptide transport process, and this process can be inhibited to various extents by other di- and tripeptides but the inhibition never exceeded 43%.
Peptide transport in rabbit kidney. Studies with L-carnosine.
TLDR
A model for peptide transport is proposed in which transport of the intact peptide across the membrane is followed by its partial or complete hydrolysis by a membrane peptidase whose active site is on the cytoplasmic side of the membrane.
Transport of glycyl-L-proline into intestinal and renal brush border vesicles from rabbit.
TLDR
Under conditions in which presence of a Na+ gradient between external and intravesicular media stimulated L-alanine transport, glycyl-L-proline transport remains unaffected and it is proposed that the Na+, gradient hypothesis of sugar and amino acid transport is not applicable for dipeptide transport.
Mechanisms of p-aminohippurate transport by brush-border and basolateral membrane vesicles isolated from rat kidney cortex.
The uptake of [3H]-labeled p-aminohippurate by brush-border and basolateral membrane vesicles isolated from rat renal cortex has been studied by a rapid filtration technique. Some characteristics of
Characteristics of dipeptide transport in normal and papain-treated brush border membrane vesicles from mouse intestine. II. Uptake of glycyl-L-leucine.
TLDR
It is concluded that intact peptide transport occurs down a concentration gradient by a non-Na+-dependent process and that passive and facilitated diffusion mechanisms, the latter either by a high affinity-low capacity system or a low affinity-high capacity system, are involved in this transport.
Carrier-mediated transport of glycyl-L-proline in renal brush border vesicles.
TLDR
Renal brush border vesicles prepared from rabbit were shown to transport intact glycyl-L-proline into the intravesicular space by a Na+-independent, carrier-mediated process, showing that this dipeptide was extremely resistant to hydrolysis.
Effect of papain treatment on dipeptide transport into rabbit intestinal brush border vesicles.
Abstract Purified rabbit intestinal brush border membrane vesicles transport glycyl-L-proline into an osmotically responsive intravesicular space by a Na+- independent, carrier-mediated process. With
Transmembrane disposition of the phlorizin binding protein of intestinal brush borders
TLDR
The absorptive epithelium of the small intestine is specialized in the transcellular transfer of a number of important nutrients, including sugars, and the main features of this uptake, including the competitive inhibition by phlorizin, are preserved in vesicular membrane preparations derived from brush borders.
...
1
2
...