Carrier-mediated norepinephrine release and reperfusion arrhythmias induced by protracted ischemia in isolated perfused guinea pig hearts: effect of presynaptic modulation by alpha(2)-adrenoceptor in mild hypothermic ischemia.

@article{Oka2002CarriermediatedNR,
  title={Carrier-mediated norepinephrine release and reperfusion arrhythmias induced by protracted ischemia in isolated perfused guinea pig hearts: effect of presynaptic modulation by alpha(2)-adrenoceptor in mild hypothermic ischemia.},
  author={Jun-ichi Oka and Michiaki Imamura and Eiichiro Hatta and Ryushi Maruyama and Mitsuhiro Isaka and Toshifumi Murashita and Keishu Yasuda},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={303 2},
  pages={681-7}
}
Yohimbine, an alpha(2)-adrenoceptor antagonist, has been reported to protect hypoxic myocardium and inhibit carrier-mediated norepinephrine (NE) release and reperfusion arrhythmias (ventricular fibrillation; VF) in normothermic ischemia. In heart surgery, mild hypothermic (tepid) cardioplegia has been reported to reduce metabolic demand and permit immediate recovery of cardiac function. Therefore, we determined the effect of yohimbine on NE release and reperfusion arrhythmias in isolated… CONTINUE READING