Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.

@article{Zierath1995CarriermediatedFU,
  title={Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.},
  author={Juleen R Zierath and Lorraine A. Nolte and E. Odegaard Wahlstr{\"o}m and D. L{\'a}szl{\'o} Galuska and P. R. Shepherd and Barbara B. Kahn and H Wallberg-henriksson},
  journal={The Biochemical journal},
  year={1995},
  volume={311 ( Pt 2)},
  pages={517-21}
}
To determine whether fructose can be utilized as a metabolic substrate for skeletal muscle in man, we investigated its incorporation into glycogen, its oxidation and lactate production in isolated human skeletal muscle. Rates of fructose oxidation and incorporation into glycogen increased in the presence of increasing fructose concentrations (0.1-1.0 mM). Lactate production increased 3-fold when extracellular fructose was increased from 0.1 to 0.5 mM. Cytochalasin B, a competitive inhibitor of… CONTINUE READING

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