Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo.

@article{Wen2017CarrierfreeSP,
  title={Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo.},
  author={Yan Wen and Wei Zhang and Ningqiang Gong and Yi-feng Wang and Hong-bo Guo and Weisheng Guo and Paul Keng Chien Wang and Xing-Jie Liang},
  journal={Nanoscale},
  year={2017},
  volume={9 38},
  pages={
          14347-14356
        }
}
Carrier-free nanodrugs formulated from the supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. We report herein a new and simple method to directly assemble a small hydrophobic anticancer drug, 10-hydroxycamptothecin (HCPT), with a photosensitizer chlorin e6 (Ce6) to form stable, discrete nanorods (NRs), which not only circumvent the extreme hydrophobicity of HCPT but also incorporate two different modalities into one… CONTINUE READING
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