Carrier detection of phenylketonuria in Iranian families by variable number tandem-repeat polymorphism analysis.

@article{HosseiniMazinani2008CarrierDO,
  title={Carrier detection of phenylketonuria in Iranian families by variable number tandem-repeat polymorphism analysis.},
  author={Seyed Mehdi Hosseini-Mazinani and Jalal Koochmeshgi and Z Khazaee-Koohpar and Nasrin Hosein-Pur-Nobari and Seyed Morteza Seifati},
  journal={Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit},
  year={2008},
  volume={14 6},
  pages={
          1445-51
        }
}
This study of Iranian families assessed the usefulness of carrier detection of phenylketonuria by variable number tandem-repeat (VNTR) polymorphism analysis. We studied 171 people (45 unrelated PKU subjects, and their parents and unaffected siblings). Of 342 chromosomes (131 non-PKU and 211 PKU), 5 VNTR alleles were identified. This VNTR system would yield a polymorphism information content of 66%, comparable to that in Europeans and higher than in Chinese. Carrier detection by segregation… CONTINUE READING

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