Carrageenin-induced arthritis. I. The effect of intraarticular carrageenin on the chemical composition of articular cartilage.

@article{Lowther1976CarrageenininducedAI,
  title={Carrageenin-induced arthritis. I. The effect of intraarticular carrageenin on the chemical composition of articular cartilage.},
  author={David A. Lowther and G. C. Gillard},
  journal={Arthritis and rheumatism},
  year={1976},
  volume={19 4},
  pages={769-76}
}
A single intraarticular injection of carrageenin into rabbit knee joints initiated a localized synovial inflammatory response. This response was accompanied by a 20% loss of proteoglycan from the articular cartilage within 24 hours and by a further 30-60% loss within 5-7 days. The chondrocytes replaced the lost proteoglycan within 42 days. More than two injections caused only a further small decrease in proteoglycan content; the cartilage was then unable to replace the lost proteoglycan. The… CONTINUE READING

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