Carrageenans inhibit growth-factor binding.

@article{Hoffman1993CarrageenansIG,
  title={Carrageenans inhibit growth-factor binding.},
  author={Richard Hoffman},
  journal={The Biochemical journal},
  year={1993},
  volume={289 ( Pt 2)},
  pages={331-4}
}
Carrageenans, a family of polysulphated carbohydrates, inhibited binding of basic fibroblast growth factor (bFGF), transforming growth factor beta 1 (TGF beta 1) and platelet-derived growth factor (PDGF). iota-Carrageenan was the most potent bFGF antagonist (IC50 = 0.4 +/- 0.1 microgram/ml), kappa-carrageenan was the most potent PDGF antagonist (IC50 = 1.7 +/- 1.3 micrograms/ml) and lambda-carrageenan was the most potent TGF beta 1 antagonist (IC50 = 19 +/- 2 micrograms/ml). None of the… CONTINUE READING

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Methods Enzymol

  • L. M. Wakefield
  • 1987
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