Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors

@article{Espeland2005CarotidIT,
  title={Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors},
  author={Mark A. Espeland and Daniel H. O'Leary and James G. Terry and Timothy M. Morgan and Greg Evans and Harald G Mudra},
  journal={Current Controlled Trials in Cardiovascular Medicine},
  year={2005},
  volume={6},
  pages={3 - 3}
}
BACKGROUND: Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickness (IMT) of the carotid artery; much experience has been gained with this endpoint in trials of HMG-CoA reductase inhibitors (statins). METHODS AND RESULTS: We examine two separate systems of criteria that have been proposed to define surrogate endpoints, based on clinical and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

: impact of statins

  • Boissel J-P, Collet J-P, P Moleur, M Haugh
  • 2003

Site-specific progression of carotid artery atherosclerosis

  • MA Espeland, LE Wagenknecht, +5 authors SM Haffner
  • Atherosclerosis
  • 2003
1 Excerpt

Similar Papers

Loading similar papers…