Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure.

@article{Marcus2014CarotidBD,
  title={Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure.},
  author={Noah J Marcus and Rodrigo Del Rio and Evan P Schultz and Xiao-hong Xia and Harold D Schultz},
  journal={The Journal of physiology},
  year={2014},
  volume={592 2},
  pages={391-408}
}
In congestive heart failure (CHF), carotid body (CB) chemoreceptor activity is enhanced and is associated with oscillatory (Cheyne-Stokes) breathing patterns, increased sympathetic nerve activity (SNA) and increased arrhythmia incidence. We hypothesized that denervation of the CB (CBD) chemoreceptors would reduce SNA, reduce apnoea and arrhythmia incidence and improve ventricular function in pacing-induced CHF rabbits. Resting breathing, renal SNA (RSNA) and arrhythmia incidence were measured… CONTINUE READING
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