Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link.

  title={Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link.},
  author={Rodrigo Del Rio and Esteban A. Moya and Rodrigo Iturriaga},
  journal={The European respiratory journal},
  volume={36 1},
Intermittent hypoxia, a feature of obstructive sleep apnoea, potentiates ventilatory hypoxic responses, alters heart rate variability and produces hypertension, partially owing to an enhanced carotid body responsiveness to hypoxia. Since oxidative stress is a potential mediator of both chemosensory and cardiorespiratory alterations, we hypothesised that an antioxidant treatment may prevent these alterations. Accordingly, we studied the effects of ascorbic acid (1.25 g.L(-1) drinking water) on… CONTINUE READING


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