Carotid Sinus Reflex Coronary Vasoconstriction during Controlled Myocardial Oxygen Metabolism in the Dog

@article{Powell1979CarotidSR,
  title={Carotid Sinus Reflex Coronary Vasoconstriction during Controlled Myocardial Oxygen Metabolism in the Dog},
  author={J R Powell and Eric O. Feigl},
  journal={Circulation Research},
  year={1979},
  volume={44},
  pages={44–51}
}
We studied carotid baroreceptor reflex coronary vasoconstriction in closed-chest dogs with controlled aortic blood pressure and myocardial oxygen metabolism. The dogs were anesthetized with morphine and chloralose. Left coronary blood flow was measured by a cannula-tip flowmeter, and myocardial oxygen metabolism was calculated by measuring the arterial-coronary sinus oxygen difference. A bilateral vagotomy was performed in all animals and they were treated with propranolol. Reduction of carotid… 
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  • Medicine, Biology
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  • 1998
TLDR
Evidence indicates that there is a beneficial effect of this paradoxical vasoconstrictor influence in that it helps preserve flow to the vulnerable inner layer of the left ventricle, but only when both heart rate and coronary flow are high.
α‐Adrenergic‐Mediated Reduction in Coronary Blood Flow Secondary to Carotid Chemoreceptor Reflex Activation in Conscious Dogs
TLDR
It is concluded that, with autonomic nervous system activity intact, carotid chemoreceptor reflex activation can elicit an absolute reflexly mediated reduction in coronary blood flow in the normal, conscious dog, despite an increase in arterial pressure.
Reflex control of coronary vascular tone by cardiopulmonary receptors in humans.
Intravenous phentolamine abolishes coronary vasoconstriction in response to mild central hypovolemia.
TLDR
The data suggest that alpha-adrenergic tone enhances coronary flow efficiency, presumably by redistributing flow from the epicardium to the endocardium.
Carotid Sinus Baroreceptor Control of Right Coronary Circulation in Normal, Hypertrophied, and Failing Right Ventricles of Conscious Dogs
The right coronary vascular response to bilateral carotid occlusion (BCO) was assessed in normal, conscious dogs and also in dogs with right ventricular (RV) hypertrophy alone or in combination with…
Alpha-adrenergic vasoconstriction in arterial and arteriolar sections of the canine coronary circulation
SummaryUsing a method which allowed the in-situ measurement of segmental coronary vascular resistances, the reaction of arterial and arteriolar sections of the coronary vascular system to α-receptor…
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