Carotenoids modulate cytokine production in Peyer's patch cells ex vivo.

  title={Carotenoids modulate cytokine production in Peyer's patch cells ex vivo.},
  author={Masaya Yamaguchi and Isao Hasegawa and Nobuo Yahagi and Yasuhito Ishigaki and Fumihide Takano and Tomihisa Ohta},
  journal={Journal of agricultural and food chemistry},
  volume={58 15},
This study investigated the effects of carotenoid and capsaicin constituents of Capsicum on intestinal immune responses in mice. Peyer's patch (PP) cells were isolated from mice orally administered with capsaicin, or one of three carotenoids (beta-carotene, beta-cryptoxanthin, or lycopene), at 5 mg/kg/day for 7 consecutive days. Collagenase-separated PP cells were then cultured in the presence or absence of concanavalin A (Con A). PP cells from mice treated with capsaicin, beta-carotene, or… 

Stilbenoids from the melinjo (Gnetum gnemon L.) fruit modulate cytokine production in murine Peyer's patch cells ex vivo.

Results indicated that this melinjo extract and its active constituent 7 potentiated T-cell-dependent immune responses in the ileal mucosa.

Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells.

A new cellular function has been attributed to lycopene for B lymphocyte biology and possibly associated with humoral responses and mucosal immunity as indicated by the pattern of peritoneal IgM+ and IgA+ B cells indicated a significant IgM-to-IgA class switching after lycopenes injection.

Pheophytin a and chlorophyll a identified from environmentally friendly cultivation of green pepper enhance interleukin-2 and interferon-γ in Peyer's patches ex vivo.

Oral administration of ECP extract significantly induced the production of IL-2 and IFN-γ in concanavalin A-treated cells from PP ex vivo; their levels were much higher than those in the CCP extract-treated group, and pheophytin a and chlorophyll a are immune-modulating components in green vegetables.

Carotenoids: biochemistry, pharmacology and treatment

The biological and immunological activities of the main carotenoids used for the treatment of various diseases and their possible mechanisms of action are described.

Lycopene affects the immune responses of finishing pigs

Dietary lycopene supplementation for finishing pigs affected the cellular and humoral immune response, and the highest anti-BSA IgG production was achieved by supplementing 20.06 mg lyCopene/kg of diet.

Upregulation of the transient receptor potential vanilloid 1 in colonic epithelium of patients with active inflammatory bowel disease.

Although TRPV1 immunoreactivity was highly expressed on epithelial cells and infiltrating inflammatory cells in colonic biopsies of active IBD patients, TRPv1 expression did not significantly correlate with disease severity (P>0.05), which indicated that further studies are clearly warranted to determine whether TRpV1 is a potential target for therapy.

Anti-inflammatory and immunomodulatory properties of Carica papaya

Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking.

Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease.

The existence of a complex web of molecules/factors that exogenously or endogenously affect oxidants is discussed, and these molecules are related to potential therapeutics.