Carotenoids/vitamin C and smoking‐related bladder cancer

  title={Carotenoids/vitamin C and smoking‐related bladder cancer},
  author={Jos{\'e} Esteban Castelao and Jian-Min Yuan and Manuela Gago-Dom{\'i}nguez and Paul L. Skipper and Steven R Tannenbaum and Kenneth K. Chan and Mary A. Watson and Douglas A. Bell and Gerhard A. Coetzee and Ronald K. Ross and Mimi C. Yu},
  journal={International Journal of Cancer},
Previous epidemiological studies of fruit and vegetable intake and bladder cancer risk have yielded inconsistent results, especially with respect to the role of cigarette smoking as a possible modifier of the diet‐bladder cancer association. A population‐based case‐control study was conducted in nonAsians of Los Angeles, California, which included 1,592 bladder cancer patients and an equal number of neighborhood controls matched to the index cases by sex, date of birth (within 5 years) and race… 

Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

The findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk.

Dietary Intake of Vegetables and Fruits and the Modification Effects of GSTM1 and NAT2 Genotypes on Bladder Cancer Risk

The data strongly support that high vegetable consumption, especially cruciferous vegetable intake, may protect against bladder cancer and that genetic variants of GSTM1 and NAT2 may modify the association.

Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer.

A reduced risk of bladder cancer was found associated with fruit and vegetable intake and the fruits and vegetables associated with decreased risks included leafy green vegetables, cruciferous vegetables, apples and citrus fruits.

Protective effects of plasma carotenoids on the risk of bladder cancer.

Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study

The findings suggest further investigation of the effect of vitamin E, carotenoids, vitamin D, thiamin, niacin, and vitamin E on bladder cancer risk may be warranted, and future studies should focus on high risk groups such as heavy smokers and older individuals.

Dietary factors associated with bladder cancer

There is no strong evidence to suggest that supplementation with any common micronutrient is effective in reducing BC risk, but the observation that a diet rich in fruits and vegetables and low in processed meat along with especially smoking cessation may convey some protective effects against BC risk is upheld.

Dietary carotenoids and genetic instability modify bladder cancer risk.

Evidence of a preventive role for carotenoids in bladder cancer is provided, and these data may have important implications for cancer prevention, especially for individuals susceptible to DNA damage.

Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer

It is concluded that fruit consumption may decrease the effect of smoking on developing bladder cancer andAntioxidants, found in fruit, may protect against the damage caused by free radicals found in cigarette smoke.

Dietary sources of N‐nitroso compounds and bladder cancer risk: Findings from the Los Angeles bladder cancer study

Results of this study are consistent with a role of dietary sources of NOC precursors from processed meats in bladder cancer risk, suggesting consumption of meats with high amine and heme content such as salami and liver as a risk factor for bladder cancer.



Cruciferous vegetables in relation to renal cell carcinoma

A significant residual effect of cruciferous vegetables is observed, suggesting that other substances present in these vegetables may be responsible, at least partially, for the observed reduction in risk of RCC.

Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study

It is suggested that fruit and vegetable intakes are not likely to be associated with bladder cancer risk, however, these results may not be generalisable to non-smokers.

Dietary factors and the incidence of cancer of the urinary bladder.

Dietary factors, with little exception, were not associated with significant alteration of risk for bladder cancer and reports of a lack of association between use of artificial sweeteners and subsequent risk of bladder cancer are confirmed.

Nutrient intake in relation to bladder cancer among middle-aged men and women.

There is modest evidence that certain nutrients, foods, and supplementation may affect the incidence of bladder cancer, and the use of multivitamin supplements daily over the 10 years before diagnosis was associated with a decreased risk.

Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study.

In women, reduced cancer risks of all sites combined and of the colon were noted for combined intake of all vegetables and fruits, fruit intake alone, and dietary vitamin C, and supplemental use of vitamins A and C showed a protective effect on colon cancer risk in women.

Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort.

Data from this study indicate that high cruciferous vegetable consumption may reduce bladder cancer risk, but other vegetables and fruits may not confer appreciable benefits against this cancer.

Dietary factors in the risk of bladder cancer.

Although available information is too uncertain for any precise definition of specific (micro)nutrients related to bladder cancer risk, the confirmation that several aspects of a less-affluent diet adversely affect the risk is still of interest in terms of a better understanding of bladder carcinogenesis.

Dietary risk factors in human bladder cancer.

The findings of this investigation are consistent with tumor inhibition by retinoids in animal studies and the low risk associated with vitamin A in epidemiologic studies of lung cancer.

Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study.

  • M. ZeegersR. GoldbohmP. A. van den Brandt
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2001
The data are suggestive of an inverse association between the consumption of brassicas, total fruit, and urothelial cancer risk, whereas total vegetable consumption did not appear to be associated with uroclinical cancer risk.

Diet in the epidemiology of bladder cancer in western New York.

Higher intake of dietary sodium was associated with increased risk among both age groups, and the trends were statistically significant, suggesting the importance of diet in the etiology of bladder cancer.