Carotenoid determination in biological microsamples using liquid chromatography with a coulometric electrochemical array detector.

@article{Ferruzzi1998CarotenoidDI,
  title={Carotenoid determination in biological microsamples using liquid chromatography with a coulometric electrochemical array detector.},
  author={Mario G Ferruzzi and Lane C Sander and Cheryl L Rock and Steven J Schwartz},
  journal={Analytical biochemistry},
  year={1998},
  volume={256 1},
  pages={74-81}
}
Numerous epidemiological studies have linked carotenoids to cancer preventive processes, thereby increasing interest in levels of these micronutrients in human tissue and serum. Conventional analyses of these biological tissues employ liquid chromatography (LC) with ultraviolet and visible absorbance (UV-VIS) detection. However, this type of carotenoid analysis does not provide adequate sensitivity for very small sample sizes, such as microscale biopsies, when only small quantities of tissue… CONTINUE READING