• Corpus ID: 212570011

Carob and its Components in the Management of Gastrointestinal Disorders

@inproceedings{Theophilou2017CarobAI,
  title={Carob and its Components in the Management of Gastrointestinal Disorders},
  author={Irene C. Theophilou and Christiana M. Neophytou and Antonis C. Kakas and Andreas Constantinou},
  year={2017}
}
Plant-derived compounds have demonstrated health benefits, including cancer preventive properties, increasing bone density, improving cardiovascular functions, reducing obesity, lowering cholesterol levels and delaying aging. Plants, fruits and their medicinal products are especially known for sustaining human health and preventing diseases. Importantly, certain plant-derived purified components, and their combinations, are also effective in the treatment of human diseases. In fact, over 60% of… 

Figures from this paper

Urine and fecal samples targeted metabolomics of carobs treated rats.

Anti-Cancer Activity and Phenolic Content of Extracts Derived from Cypriot Carob (Ceratonia siliqua L.) Pods Using Different Solvents

The results indicate that extracts from Cypriot carobs may have potential uses in the development of nutritional supplements and pharmaceuticals, and demonstrate that the anti-proliferative capacity of carob extracts varied with the stage ofcarob maturity and the extraction solvent.

Nutritional characterization of carobs and traditional carob products

Carobs can be characterized as functional foods with low‐fat content, high content in dietary fibers, and high content and/or source of minerals; however, carob products partially satisfied those health and nutritional claims as expected.

Antioxidant activity of carob seeds and chemical composition of their bean gum by– products

Aqueous acetonicextract of carob seeds give the highest contents of total phenolics, total flavonoids, flavonols, total tannins and condensed tannin and the same extract showed the best antioxidant activity in all assays compared to other extracts.

Carob pests in the Mediterranean region: bio-ecology, natural enemies and management options

An overview on the bio-ecology, natural enemies and pest contol tools of the main pests infesting carob tree (Ceratonia siliqua L.), pods and seeds in the Mediterranean region is provided herein.

Pod Morphology, Primary and Secondary Metabolite Profiles in Non-grafted and Grafted Carob Germplasm Are Configured by Agro-Environmental Zone, Genotype, and Growing Season

The present study provides a comprehensive insight into the extant carob genetic resources of Cyprus and advances the understanding of how genetic, agro-environmental and seasonal factors interact in shaping carob pod morphology and composition.

Therapeutic Potential of Aqueous Extract of Carob inTreating Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) exists in patients and it is clinically presented to exhibit some chronic abdominal pain symptoms as well as and altered bowel habits

Heat- and Ultrasound-Assisted Aqueous Extraction of Soluble Carbohydrates and Phenolics from Carob Kibbles of Variable Size and Source Material

Examination of the impact of source material, kibble size, temperature, and duration on the efficiency of extracting sugars and phenolics aqueously by conventional heat-assisted and ultrasound-assisted methods found source material was the most influential factor determining the concentration of phenolics extracted by either method.

Configuration of the Volatile Aromatic Profile of Carob Powder Milled From Pods of Genetic Variants Harvested at Progressive Stages of Ripening From High and Low Altitudes

This study examines the VOCs composition of powder milled from pods of two genotypes cultivated at 15 and 510 m altitude and harvested at six progressive stages of maturity, finding that higher altitude enhances the characteristic carob-like aroma and sensory quality of carob powder.

Mapping the Primary and Secondary Metabolomes of Carob (Ceratonia siliqua L.) Fruit and Its Postharvest Antioxidant Potential at Critical Stages of Ripening

Changes unraveled significant episodes in the ripening-related secondary metabolism of the carob fruit and highlighted the value of immature carob as a potent source of gallotannins, with putative in vivo anti-inflammatory action, and of catechins beneficial in preventing and protecting against diseases caused by oxidative stress.

References

SHOWING 1-10 OF 60 REFERENCES

Functional Components of Carob Fruit: Linking the Chemical and Biological Space

The beneficial and health-promoting effects of carob along with the clinical trials and the drug formulations derived from carob's natural components are presented in this review.

Risks and safety of polyphenol consumption.

This article gives an overview of the potential hazards of polyphenol consumption, as reported during the round-table discussion at the 1st International Conference on Polyphenols and Health, held in

Preventive effect of carob (Ceratonia siliqua L.) in dextran sulfate sodium-induced ulcerative colitis in rat

It was concluded that CPAE consumption limits DSS-induced colonic damage in rats and the antioxidant and anti-inflammatory properties of polyphenols may play a role in this effect.

Carob pulp preparation for treatment of hypercholesterolemia

The lipid-lowering effect of a carob pulp preparation rich in insoluble dietary fiber and polyphenols was investigated in a noncomparative, open-label pilot study and may have value in the dietary treatment of hypercholesterolemia.

Does an extract of carob (Ceratonia siliqua L.) have chemopreventive potential related to oxidative stress and drug metabolism in human colon cells?

In conclusion, carob extract and its major phenolic ingredient GA modulate gene expression and protect colon adenoma cells from genotoxic impact of H(2)O(2).

Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents

A summary of current and emerging therapies in this field includes therapies targeting gastrointestinal mucosal chloride channels and guanylate cyclase-C receptors, as well as highly selective agents influencing serotonergic transmission that, at the time of writing, do not appear to have any severe deleterious effects.

In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium‐induced colitis

Inhibition of oxidative burst activity with acteoside reduced mucosal tissue damage in DSS colitis and could be a therapeutic alternative for IBD treatment.

Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)

All dietary flavonoid studied show a significant antioxidant effect in a chemical model system, but only epigallocatechin gallate or gallic acid are able to interfere with the cell cycle in Caco2 cell lines, suggesting that the antioxidant activity of flavonoids is not related to the inhibition of cellular growth.

Effects of aqueous extracts from Ceratonia siliqua L. pods on small intestinal motility in rats and jejunal permeability in mice

The results indicate that carob possesses significant laxative and anti-diarrheal activities due to its opposite effects both on gastrointestinal propulsion and permeability and confirm that the degree of maturity of carob characterized by a different phytochemical composition may be responsible for these actions.

Phenol antioxidant quantity and quality in foods : Vegetables

Fruits and vegetables in the diet have been found in epidemiology studies to be protective against several chronic diseases. Epidemiological evidence suggests that flavonoid consumption in the diet
...