Carnosine release from olfactory bulb synaptosomes is calcium-dependent and depolarization-stimulated.

@article{Rochel1982CarnosineRF,
  title={Carnosine release from olfactory bulb synaptosomes is calcium-dependent and depolarization-stimulated.},
  author={Smadar Rochel and Frank L. Margolis},
  journal={Journal of neurochemistry},
  year={1982},
  volume={38 6},
  pages={1505-14}
}
The dipeptide carnosine (beta-alanyl-L-histidine) has been proposed as a neurotransmitter in the mammalian olfactory pathway. Therefore, the efflux of in vivo-synthesized [14C]carnosine from mouse olfactory bulb synaptosomes was investigated. Carnosine was found to be released from the olfactory bulb synaptosomes by two mechanisms. The first is a slow spontaneous process that is independent of depolarization. The rate of this release was doubled in the presence of 1 mM external carnosine… CONTINUE READING

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