Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling

@article{Kulebyakin2012CarnosinePN,
  title={Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling},
  author={Konstantin Y. Kulebyakin and Larisa Karpova and Ekaterina Lakonsteva and Mikhail Yu Krasavin and Alexander A. Boldyrev},
  journal={Amino Acids},
  year={2012},
  volume={43},
  pages={91-96}
}
Carnosine is a known protector of neuronal cells against oxidative injury which prevents both apoptotic and necrotic cellular death. It was shown earlier that carnosine serves as an intracellular buffer of free radicals. Using the model of ligand-dependent oxidative stress in neurons, we have shown that homocysteine (HC) initiates long-term activation of extracellular signal regulated kinase, isoforms 1 and 2 (ERK 1/2) and Jun N-terminal kinase (JNK) which corresponds to exitotoxic effect… 

Carnosine influences transcription via epigenetic regulation as demonstrated by enhanced histone acetylation of the pyruvate dehydrogenase kinase 4 promoter in glioblastoma cells

It is demonstrated for the first time that carnosine influences epigenetic regulation via increased histone acetylation in glioblastoma cell lines U87 and T98G.

Physiological and therapeutic effects of carnosine on cardiometabolic risk and disease

Carnosine has potential preventative and therapeutic benefits in obesity, insulin resistance, T2DM and diabetic microvascular and macrovascular complications (CVD and stroke) as well as number of neurological and mental health conditions.

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