Carnosine prevents testicular oxidative stress and advanced glycation end product formation in D‐galactose‐induced aged rats

  title={Carnosine prevents testicular oxidative stress and advanced glycation end product formation in D‐galactose‐induced aged rats},
  author={Ahmet Aydın and Canan K{\"u}ç{\"u}kgergin and Jale Çoban and Işın DOĞAN-EKİCİ and Semra DOĞRU-ABBASOĞLU and M{\"u}jdat Uysal and N Koçak-Toker},
D‐Galactose is shown to mimic natural ageing in rodents by exacerbating oxidative stress and glycation. Steroid production and having a poor antioxidant system make testis vulnerable to galactose‐induced ageing. Antioxidation and antiglycating actions of carnosine may be intriguing for prevention of testicular ageing. In this study, male Wistar rats were applied D‐galactose (300 mg/kg; subcutaneously 5 days a week) and carnosine (250 mg/kg; intraperitoneally 5 days a week) along with D… 

The possible ameliorative effect of carnosine in protein deficient diet induced testicular damage.

Carnosine could be used as complementary supplements in malnutrition for protection against PDD induced testicular atrophy in male albino rats.

DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-κB Pathway

The results suggest that DL0410 exerts neuroprotective effects against hippocampus and cortex injury induced by D-galactose, and the possible mechanisms include antioxidative stress, antineuroinflammation, improving synaptic plasticity, and maintaining BBB integrity, which is mediated by the TLR4/MyD88/NF-κB signaling pathway inhibition.

Carnosine and diabetic nephropathy.

This review highlights the recent knowledge on the role of the carnosine metabolism in DN and first intervention studies in (pre-) diabetic patients yielded promising results.

Characteristics of Selected Antioxidative and Bioactive Compounds in Meat and Animal Origin Products

The antioxidant activity of meat components results, among others, from the capability of scavenging reactive oxygen and nitrogen species, forming complexes with metal ions and protecting cells against damage.

Energy Metabolism and Autism: The Ameliorative Potential of Carnosine and Agmatine

  • Hipkiss Ar
  • Biology
    Journal of Neurology and Neurocritical Care
  • 2018
Dietary supplementation studies with carnosine and arginine (agmatine precursor) indicate ameliorative activity towards behaviour in ASD subjects, and it is suggested that co-administration of Carnival and agmatine should be explored as a potential route for ASD amelIORation.



Carnosine and vitamin E – a promising pair in the combat against testicular oxidative stress in aged rats

Carnosine plus vitamin E treatment appears to stage a powerful performance by attenuating testicular oxidative stress and sparing the antioxidant system.

Advanced glycation in d-galactose induced mouse aging model

Advanced glycation end products inhibit testosterone secretion by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress.

It can be concluded that AGEs inhibit testosterone production by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress.

Total flavonoids of Epimedium reduce ageing‐related oxidative DNA damage in testis of rats via p53‐dependent pathway

Intragastric administration of TFE for 6 months significantly improved testicular morphology, increased the activities of SOD and decreased the levels of MDA of testis, suggesting inhibition of oxidative DNA damage is likely to represent a promising strategy for restoration of ageing‐related testicular dysfunction.

Ferulic acid in the treatment of post‐diabetes testicular damage: relevance to the down regulation of apoptosis correlates with antioxidant status via modulation of TGF‐β1, IL‐1β and Akt signalling

The result suggests that ferulic acid inhibits testicular damage in diabetic rats by declining oxidative stress by using terminal deoxyuridine triphosphate nick end‐labelling.

The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats

In conclusion, carnosine treatment was found to be useful in the decrease of age-related oxidative stress in the liver and non-enzymatic and enzymatic antioxidants did not change in heart and brain of aged rats.

The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes.

Osmanthus fragrans Flower Extract and Acteoside Protect Against d-Galactose-Induced Aging in an ICR Mouse Model.

OFE, rich in acteoside, was a good source of natural antiaging compounds and inhibited d-galactose-induced neurological aging by suppressing the increase in glial fibrillary acidic protein and neurotrophin-3.

White tea consumption restores sperm quality in prediabetic rats preventing testicular oxidative damage.

Carnosine reacts with protein carbonyl groups:another possible role for the anti-ageing peptide?

The proposal may point to a hithertounrecognised mechanism by which cells/organismsnormally defend themselves against protein carbonyls.