Carnosine prevents testicular oxidative stress and advanced glycation end product formation in D‐galactose‐induced aged rats

  title={Carnosine prevents testicular oxidative stress and advanced glycation end product formation in D‐galactose‐induced aged rats},
  author={Ahmet Aydın and Canan K{\"u}ç{\"u}kgergin and Jale Çoban and Işın Doğan-Ekici and Semra Doǧru-Abbasoǧlu and M{\"u}jdat Uysal and Necla Koçak-Toker},
D‐Galactose is shown to mimic natural ageing in rodents by exacerbating oxidative stress and glycation. Steroid production and having a poor antioxidant system make testis vulnerable to galactose‐induced ageing. Antioxidation and antiglycating actions of carnosine may be intriguing for prevention of testicular ageing. In this study, male Wistar rats were applied D‐galactose (300 mg/kg; subcutaneously 5 days a week) and carnosine (250 mg/kg; intraperitoneally 5 days a week) along with D… 

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Carnosine plus vitamin E treatment appears to stage a powerful performance by attenuating testicular oxidative stress and sparing the antioxidant system.

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