Carnosine modulates glutamine synthetase expression in senescent astrocytes exposed to oxygen-glucose deprivation/recovery.

@article{Shi2017CarnosineMG,
  title={Carnosine modulates glutamine synthetase expression in senescent astrocytes exposed to oxygen-glucose deprivation/recovery.},
  author={Xiaojie Shi and Bingyu Wang and Yuan Liu and Jingjing Zhang and Yuyan Huang and Pei Rang Cao and Yao Shen and Jianxin Lyu},
  journal={Brain research bulletin},
  year={2017},
  volume={130},
  pages={138-145}
}
Carnosine is believed to be neuroprotective in cerebral ischemia. However, few reports concern its function on senescent astrocytes during cerebral ischemia. The aim of this study was to investigate the effects of carnosine on cell damage and glutamine synthetase (GS) expression in D-galactose-induced senescent astrocytes exposed to oxygen-glucose deprivation/recovery (OGD/R). The results showed that OGD/R caused massive cell damage and a significant decrease in GS expression both in the young… CONTINUE READING