Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells.

  title={Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells.},
  author={Gary P. Zaloga and Pamela R. Roberts and Kimberly W. Black and M. Lin and Gisele Zapata-Sudo and Roberto T Sudo and Thomas E. Nelson},
  journal={The American journal of physiology},
  volume={272 1 Pt 2},
Myocardial contractile failure is a common cause of morbidity and mortality in patients with ischemic heart disease and systemic inflammatory states such as sepsis. Accumulating evidence indicates that contractile failure is associated with dysregulation of myoplasmic calcium levels. In a search for biochemical causes for contractile dysfunction, we found that the dipeptide carnosine improves cardiac contractility and tested the possibility that carnosine plays a role in the regulation of… 

An unknown endogenous inhibitor of Na/Ca exchange can enhance the cardiac muscle contractility.

The present findings demonstrate that the mammalian heart contains a low-molecular-weight factor that can inhibit Na/Ca exchange and enhance the cardiac contractility.

Physiological Roles of Carnosine in Myocardial Function and Health

The role of carnosine in myocardial function and health is discussed, including an overview of the metabolic pathway, the roles carnosines may play in the myocardium, and a critical analysis of the literature, focusing on the effect of exogenous carnsine and its precursors on myocardIAL function.

Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization

The data suggest that carnosine promotes post ischemic revascularization via augmentation of pro-angiogenic HIF-1α/VEGF signaling, possibly by Fe2+ chelation, as well as enhanced blood flow recovery and limb function following HLI surgery.

Contribution of Reactive Oxygen Species to Isoflurane-induced Sensitization of Cardiac Sarcolemmal Adenosine Triphosphate–sensitive Potassium Channel to Pinacidil

These results suggest that reactive oxygen species contribute to the mechanism by which isoflurane sensitizes the cardiac sarcolemmal KATP channel to the opener, pinacidil.

Inhibition of nitric oxide synthase enhances the myocardial toxicity of phenylpropanolamine

Inhibition of nitric oxide synthesis sensitizes the heart to the myocardial depressant effects of PPA and increases the risk for ventricular fibrillation.

Carnosine and its possible roles in nutrition and health.

  • A. Hipkiss
  • Biology
    Advances in food and nutrition research
  • 2009

Physiology and pathophysiology of carnosine.

This paper summarizes a century of scientific exploration on the (patho)physiological role of carnosine and related compounds, and concludes that far more experiments are required to gain a full understanding of the function and applications of this intriguing molecule.

The new compound, LASSBio 294, increases the contractility of intact and saponin‐skinned cardiac muscle from Wistar rats

A novel mechanism for a positive cardioinotropic effect through an interaction with the Ca2+ uptake/release process of the SR is suggested and could be explained by a pronounced increased accumulation ofCa2+ into the SR.