Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

@article{Ditte2013CarnosineIC,
  title={Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts},
  author={Zuzana Ditte and Peter Ditte and Martina Labudov{\'a} and Veronika Simko and Filippo Iuliano and Miriam Zaťovi{\vc}ov{\'a} and Lucia Csaderova and Silvia Pastorekov{\'a} and Jaromir Pastorek},
  journal={BMC Cancer},
  year={2013},
  volume={14},
  pages={358 - 358}
}
BackgroundCarbonic anhydrase IX (CA IX) is a transmembrane enzyme that is present in many types of solid tumors. Expression of CA IX is driven predominantly by the hypoxia-inducible factor (HIF) pathway and helps to maintain intracellular pH homeostasis under hypoxic conditions, resulting in acidification of the tumor microenvironment. Carnosine (β-alanyl-L-histidine) is an anti-tumorigenic agent that inhibits the proliferation of cancer cells. In this study, we investigated the role of CA IX… 

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