Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

  title={Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts},
  author={Zuzana Ditte and Peter Ditte and Martina Labudov{\'a} and Veronika Simko and Filippo Iuliano and Miriam Zaťovi{\vc}ov{\'a} and Lucia Csaderova and Silvia Pastorekov{\'a} and Jaromir Pastorek},
  journal={BMC Cancer},
  pages={358 - 358}
BackgroundCarbonic anhydrase IX (CA IX) is a transmembrane enzyme that is present in many types of solid tumors. Expression of CA IX is driven predominantly by the hypoxia-inducible factor (HIF) pathway and helps to maintain intracellular pH homeostasis under hypoxic conditions, resulting in acidification of the tumor microenvironment. Carnosine (β-alanyl-L-histidine) is an anti-tumorigenic agent that inhibits the proliferation of cancer cells. In this study, we investigated the role of CA IX… 

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It is shown that dexamethasone treatment leads to concentration-dependent downregulation of cancer-associated marker, carbonic anhydrase IX (CA IX), at the level of promoter activity, mRNA and protein expression in 2D and 3D cancer cell models and a potential NF-κB binding site in the CA9 promoter is identified.

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Carnosine’s anti-neoplastic effect is independent from PI3K/Akt/mTOR signaling and should be considered for therapy, especially as it is a naturally occurring compound that has already been used for the treatment of other diseases without indication of side-effects.

The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells

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Chemotherapeutic potential of L-carnosine from stimuli-responsive magnetic nanoparticles against breast cancer model.

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This review summarizes research data related to distribution, regulation and functional aspects of CA IX and CA XII, and describes emerging possibilities for clinical exploitation of CA inhibitors as imaging tools and anticancer drugs.

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

  • L. DuboisS. Peeters P. Lambin
  • Medicine, Biology
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • 2011

Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain*

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Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin.

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Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target

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Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

A new class of HIF-1-responsive gene is defined, the activation of which has implications for the understanding of hypoxic tumor metabolism and which may provide endogenous markers for tumor hypoxia.

Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine.

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Carnosine inhibits ATP production in cells from malignant glioma

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