Carnosine increases efficiency of temozolomide and irradiation treatment of isocitrate dehydrogenase-wildtype glioblastoma cells in culture.

  title={Carnosine increases efficiency of temozolomide and irradiation treatment of isocitrate dehydrogenase-wildtype glioblastoma cells in culture.},
  author={Johannes Dietterle and Henry Oppermann and Annegret Glasow and Karsten Neumann and J{\"u}rgen Meixensberger and Frank Gaunitz},
  journal={Future oncology},
Aim: The naturally occurring dipeptide carnosine (CAR) has been considered for glioblastoma therapy. As CAR also protects against ionizing irradiation (IR), we investigated whether it may counteract standard therapy consisting of postsurgery IR and treatment with temozolomide (TMZ). Materials & methods: Four isocitrate dehydrogenase-wildtype primary cell cultures were exposed to different doses of IR and different concentrations of TMZ and CAR. After exposure, viability under the different… 



Carnosine Inhibits Growth of Cells Isolated from Human Glioblastoma Multiforme

Since carnosine is a naturally occurring substance that appears to be non-toxic to normal tissue and is able to penetrate the blood–brain barrier it may be a candidate for a therapeutic agent that may reduce proliferation of neoplastic cells even in vivo and especially in cases of glioblastoma multiforme.

Carnosine selectively inhibits migration of IDH-wildtype glioblastoma cells in a co-culture model with fibroblasts

It is demonstrated that the anti-proliferative effect of carnosine is not accompanied by an induction of cell migration, and the dipeptide is able to prevent colony formation and selectively eliminates tumor cells in a co-culture with fibroblasts.

The Anti-Proliferative Effect of L-Carnosine Correlates with a Decreased Expression of Hypoxia Inducible Factor 1 alpha in Human Colon Cancer Cells

Findings suggest that an analysis of L-carnosine antioxidant pathway will clarify the mechanism underlying the anti-proliferative effects of this dipeptide on colon cancer cells and may be promising in treating hypoxia-related diseases.

Carnosine Inhibits the Proliferation of Human Gastric Cancer SGC-7901 Cells through Both of the Mitochondrial Respiration and Glycolysis Pathways

The results suggested that carnosine is a potential regulator of energy metabolism of SGC-7901 cells both in the anaerobic and aerobic pathways, and provided a clue for preclinical and clinical evaluation of carnosines for gastric cancer therapy.

Stimulating action of carnosine on hematopoietic stem cells

The effect of this substance on hematopoietic stem cells, when administered in different ways, was studied to obtain a wider picture of the mechanism of action of carnosine as a radioprotector.

Carnosine may reduce lung injury caused by radiation therapy.

MGMT gene silencing and benefit from temozolomide in glioblastoma.

Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylation of theMGMT promoter did notHave such a benefit and were assigned to only radiotherapy.

[The radiation modifying properties of carnosine].

The influence of carnosine (beta-alanyl-l-histidine) on the survival rate of albino mice subjected to whole-body X-irradiation has been investigated and produced an insignificant protective effect and caused inhibition of the postirradiated histamine accumulation in the spleen.

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model

As a naturally occurring substance with a high potential to inhibit growth of malignant cells in vivo, carnosine should be considered as a potential anti-cancer drug.

Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

Interaction of carnosine with CA IX leads to conformational changes of CA IX and impaired formation of its metabolon, which in turn disrupts CA IX function, suggesting an inhibitory effect on CA IX-mediated acidosis.