Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis.

  title={Carnosine exerts antitumor activity against bladder cancers in vitro and in vivo via suppression of angiogenesis.},
  author={Byungdoo Hwang and Seung S. Shin and Jun-Hui Song and Yung-Hyun Choi and Wun-Jae Kim and Sung-Kwon Moon},
  journal={The Journal of nutritional biochemistry},
Carnosine, a naturally occurring dipeptide, was recently reported to exhibit anticancer activity; however, the molecular mechanisms and regulators underlying its activity against tumor-associated angiogenesis remain unidentified. In this study, we evaluated the in vitro and in vivo antitumor effects of carnosine in EJ bladder cancer cells and EJ-xenografted BALB/c nude mice, respectively. In addition, in vitro capillary tube formation of HUVECs, ex vivo aortic ring and in vivo Matrigel plug… Expand
3 Citations
Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
The present review aimed to provide recent knowledge on carnosine properties and distribution, its metabolism (synthesis and degradation), and analytical methods for Carnosine determination, since one of the difficulties is the measurement of carnosines concentration in human samples. Expand
The free amino acid profiles and metabolic biomarkers of predicting the chemotherapeutic response in advanced sarcoma patients
Three amino acids including Car, GABA and Abu may be metabolic biomarkers playing a role in dynamic monitoring of the therapeutic effect in sarcoma patients and may provide ideas for clinical drugs targeting therapy. Expand
Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies
  • S. Yee, Dina Buitrago, +5 authors K. Giacomini
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2020
It is demonstrated that SLC22A15 may play an important role in determining the systemic and tissue levels of ergothioneine, carnitine, and other zwitterions, as well as four cations, including MPP+, thiamines, and cimetidine, as substrates of SLC 22A15. Expand


L-Carnosine Prevents the Pro-cancerogenic Activity of Senescent Peritoneal Mesothelium Towards Ovarian Cancer Cells.
L-carnosine may be a valuable anticancer drug, especially in the context of prevention and therapy of intraperitoneal ovarian cancer metastasis, and may be linked with decreased secretion of various pro-cancerogenic agents by HPMCs. Expand
Investigations on in vitro anti-carcinogenic potential of l-carnosine in liver cancer cells
It is demonstrated that l-carnosine exerts anti-carcinogenic effects in human liver cancer cells and is confirmed by results from mitochondrial fragmentation assay. Expand
Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression
It is suggested that carnosine can inhibit mesangial cell proliferation by modulating cell cycle progress, indicating that Carnival could be a potential therapeutic agent for the prevention of diabetic nephropathy in the early stage. Expand
Carnosine Inhibits the Proliferation of Human Gastric Cancer SGC-7901 Cells through Both of the Mitochondrial Respiration and Glycolysis Pathways
The results suggested that carnosine is a potential regulator of energy metabolism of SGC-7901 cells both in the anaerobic and aerobic pathways, and provided a clue for preclinical and clinical evaluation of carnosines for gastric cancer therapy. Expand
Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3β.
Boldine-induced inhibition of cell growth and cell cycle arrest appears to be linked to inactivation of extracellular signal-regulated kinase protein (ERK) and the efficacy of boldine in apoptosis-induced in T24 cells is correlated with modulation of AKT (inactivation) and glycogen synthase kinase-3 β (GSK-3β) (activation) proteins. Expand
Carnosine inhibits KRAS-mediated HCT116 proliferation by affecting ATP and ROS production.
The findings support the concept that carnosine could inhibit HCT116 cell growth via its antioxidant activity and its ability to affect glycolysis. Expand
A prostate secretory protein94‐derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: Implication in tumor angiogenesis
It is shown that, in a syngeneic in vivo model of rat prostate cancer, the expression of endothelial cell (EC) specific CD31, a marker of tumor vessel density, was decreased by 43% in PCK3145‐treated animals, demonstrating that PCK 3145 interferes with the tyrosine kinase activity associated with VEGF signalling axis in EC. Expand
[Antineoplastic effects of carnosine and beta-alanine--physiological considerations of its antineoplastic effects].
  • K. Nagai, T. Suda
  • Chemistry, Medicine
  • Nihon seirigaku zasshi. Journal of the Physiological Society of Japan
  • 1986
The agents showed potent antineoplastic effects on Sarcoma-180 when the tumor had been attenuated in vivo with mitomycin C (MMC) and enhanced when administered in combination with the non-specific active immuno-enhancing agent OK-432. Expand
Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines.
The results suggest that 5-FU-induced changes in cell cycle regulation of oral cancer cells might associate with an alteration of G1 cyclins expression. Expand
Inhibition of tumour cell growth by carnosine: some possible mechanisms
It is possible, by acting at various sites that this pluripotent dipeptide may be an example of an endogenous “smart drug”, which would decrease ATP supply and generation of metabolic intermediates required for continued cell reproduction. Expand