Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans

@article{Mannion2004CarnosineAA,
  title={Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans},
  author={Anne F. Mannion and Philip M Jakeman and Mark Dunnett and R. C. Harris and P. L. T. Willan},
  journal={European Journal of Applied Physiology and Occupational Physiology},
  year={2004},
  volume={64},
  pages={47-50}
}
SummaryThe content of anserine and carnosine in the lateral portion of the quadriceps femoris muscle of 50 healthy, human subjects has been studied. [] Key Result Anserine was undetectable in all muscle samples examined. Muscle carnosine values for the group conformed to a normal distribution with a mean (SD) value of 20.0 (4.7) mmol · kg−1 of dry muscle mass.
THE CARNOSINE CONTENT OF VASTUS LATERALIS IS ELEVATED IN RESISTANCE‐TRAINED BODYBUILDERS
TLDR
The carnosine contents measured are the highest recorded in human muscle and represent a 20% contribution to muscle buffering capacity, and Taurine was 38% lower in bodybuilders, though the difference was not significant.
Determinants of muscle carnosine content
TLDR
The main determinant of muscle carnosine (M-Carn) content is undoubtedly species, with aerobically trained female vegetarian athletes having just 1/10th of that found in trained thoroughbred horses.
EFFECT OF CARNOSINE CONCENTRATION IN MUSCLE AND IMPROVEMENT OF EXERCISE PERFORMANCES DUE TO LONG-TERM INTAKE OF CHICKEN BREAST EXTRACT
TLDR
It is suggested that exercise performance depends on carnosine concentration in the muscle, and that taking carnosinesine-containing foods may improve exercise performance.
The Effect of Sprint Training on Skeletal Muscle Carnosine in Humans
TLDR
The results suggest that the increases in skeletal muscle carnosine concentration following sprint training may be associated with the increase in sustainability of high power during 30-s maximal cycle ergometer sprinting.
Effect of beta-alanine and carnosine supplementation on muscle contractility in mice.
TLDR
Comparable with humans, beta-alanine availability seems to be the rate-limiting step for synthesis of muscle histidine-containing dipeptides in mice, which moderately and muscle dependently affects excitation-contraction coupling and fatigue.
Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity
TLDR
The increase in TWD with supplementation followed the increase in muscle carnosine, which was significantly increased by +58.8% and +80.1% after 4 and 10 wks β-alanine supplementation.
Hormonal Responses to Resistance Exercise after Ingestion of Carnosine and Anserine
TLDR
It is suggested that short-term supplementation with CBEX attenuates the exercise-induced epinephrine, norepinephrine, and growth hormone responses.
Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women
TLDR
Results indicated that greater intramuscular carnosine content was reflective of greater dietary protein intake and that individuals with higher carnosined content displayed a greater attenuation of fatigue compared to those with lower carnosines.
Carnosine and taurine contents of type I, IIA and IIB fibres in the middle gluteal muscle
TLDR
Higher carnosine contents in type II fibres emphasise the importance of carnosines to intramuscular acid-base regulation, and their appearance in plasma may be useful in diagnosing types I or II fibre damage.
Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans
TLDR
Muscular carnosine levels are not related to the polymorphism of the CNDP1 gene or to the enzymatic activity of the plasma carnosinase, whereas vegetarianism, female gender and increasing age are the factors associated with reduced muscle Carnosine stores.
...
...

References

SHOWING 1-10 OF 24 REFERENCES
The significance of carnosine and anserine in striated skeletal muscle.
  • C. L. Davey
  • Biology
    Archives of biochemistry and biophysics
  • 1960
Factors affecting anserine and carnosine levels in skeletal muscles of various animals
Buffering capacity of deproteinized human vastus lateralis muscle.
TLDR
Findings indicate that the sprinters and rowers possess elevated buffering capabilities and carnosine levels compared with marathon runners and untrained subjects.
The buffering of muscle in rigor; protein, phosphate and carnosine
TLDR
The buffering system of mammalian muscle in rigor mortis is much simpler than that of living muscle and more susceptible of analysis, whilst still affording much information relevant to the conditions present tn vivo.
Human variation in skeletal muscle fiber-type proportion and enzyme activities.
TLDR
The results reveal the existence of large interindividual variability and gender differences in the most common characteristics of the human skeletal muscle.
Effects of carnosine and anserine on muscle adenosine triphosphatases.
Carnosine content of the middle gluteal muscle in thoroughbred horses with relation to age, sex and training.
Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values.
TLDR
Variation in muscle content of ATP, ATP + ADP + AMP, phosphorylcreatine (PC), creatine (Cr), PC + Cr, and glycogen, between legs, between sites on the same muscle, or as a result of error introduced during analysis, was small compared with the between-individuals variance.
Regulation of muscle phosphorylase activity by carnosine and anserine.
...
...