Carnosine ameliorates morphine-induced conditioned place preference in rats
@article{Gong2007CarnosineAM, title={Carnosine ameliorates morphine-induced conditioned place preference in rats}, author={Ying-xia Gong and Hui-juan Wang and Yong-ping Zhu and Wei-Ping Zhang and Haibin Dai and Shihong Zhang and Er-qing Wei and Zhong Chen}, journal={Neuroscience Letters}, year={2007}, volume={422}, pages={34-38} }
11 Citations
Morphine induces conditioned place preference behavior in histidine decarboxylase knockout mice
- Biology, PsychologyNeuroscience Letters
- 2010
Carnosine has antinociceptive properties in the inflammation-induced nociceptive response in mice.
- BiologyEuropean journal of pharmacology
- 2012
Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity.
- Biology, ChemistryFree radical biology & medicine
- 2010
Carnosine and l-arginine attenuate the downregulation of brain monoamines and gamma aminobutyric acid; reverse apoptosis and upregulate the expression of angiogenic factors in a model of hemic hypoxia in rats
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 2019
CAR, ARG, and, importantly, their combination could effectively protect against hypoxia-induced neurotoxicity, via their angiogenic, anti-inflammatory, and anti-apoptotic properties in addition to reversing the effect on GABA and monoamines.
Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice
- Biology, PsychologyActa Pharmacologica Sinica
- 2010
It is suggested that morphine withdrawal specifically impairs cued fear extinction and histamine ameliorates this impairment, and its action might be mediated by the modulation of ERK phosphorylation in the amygdala.
The dimethylarginine (ADMA)/nitric oxide pathway in the brain and periphery of rats with thioacetamide-induced acute liver failure: Modulation by histidine
- BiologyNeurochemistry International
- 2015
Effects of carnosine on long-term plasticity of medial perforant pathway/dentate gyrus synapses in urethane-anesthetized rats: an in vivo model
- BiologyExperimental Brain Research
- 2009
The present experiment provides the first evidence that carnosine may play a role in synaptic plasticity in dentate gyrus in vivo and decreases LTP by inhibiting sGC activation.
Involvement of the brain histaminergic system in addiction and addiction-related behaviors: A comprehensive review with emphasis on the potential therapeutic use of histaminergic compounds in drug dependence
- Biology, PsychologyProgress in Neurobiology
- 2010
L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: A double-blind, randomized placebo-controlled trial
- Psychology, MedicinePsychiatry Research
- 2018
References
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Endogenous histamine inhibits the development of morphine-induced conditioned place preference
- Biology, ChemistryActa Pharmacologica Sinica
- 2007
Results indicate that endogenous histamine plays a role in inhibiting the development of morphine-induced reward-seeking behavior, and the inhibition may involve the modulation of dopaminergic activity.
Effects of carnosine on amygdaloid-kindled seizures in Sprague–Dawley rats
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Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat
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Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors.
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Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference
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It is concluded that gabapentin-like compounds, which have no intrinsic rewarding properties, may have some therapeutic use in the treatment of opioid dependence.
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L-histidine attenuates the effects of pentazocine on rewarding brain-stimulation.
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Neuroprotective effect of carnosine on necrotic cell death in PC12 cells
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The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward
- Biology, PsychologyPsychopharmacology
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The data confirm previous results demonstrating that HDC KO mice show reduced exploratory behaviors, but contrary to the hypothesis that histamine plays an inhibitory role in reward, histamine-deficient mice were not more responsive to the psychostimulant effects of cocaine.