Carnosine ameliorates morphine-induced conditioned place preference in rats

  title={Carnosine ameliorates morphine-induced conditioned place preference in rats},
  author={Ying-xia Gong and Hui-juan Wang and Yong-ping Zhu and Wei-Ping Zhang and Haibin Dai and Shihong Zhang and Er-qing Wei and Zhong Chen},
  journal={Neuroscience Letters},

Carnosine has antinociceptive properties in the inflammation-induced nociceptive response in mice.

Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity.

Carnosine and l-arginine attenuate the downregulation of brain monoamines and gamma aminobutyric acid; reverse apoptosis and upregulate the expression of angiogenic factors in a model of hemic hypoxia in rats

CAR, ARG, and, importantly, their combination could effectively protect against hypoxia-induced neurotoxicity, via their angiogenic, anti-inflammatory, and anti-apoptotic properties in addition to reversing the effect on GABA and monoamines.

Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice

It is suggested that morphine withdrawal specifically impairs cued fear extinction and histamine ameliorates this impairment, and its action might be mediated by the modulation of ERK phosphorylation in the amygdala.

Effects of carnosine on long-term plasticity of medial perforant pathway/dentate gyrus synapses in urethane-anesthetized rats: an in vivo model

The present experiment provides the first evidence that carnosine may play a role in synaptic plasticity in dentate gyrus in vivo and decreases LTP by inhibiting sGC activation.

Endogenous opiates and behavior: 2007



Endogenous histamine inhibits the development of morphine-induced conditioned place preference

Results indicate that endogenous histamine plays a role in inhibiting the development of morphine-induced reward-seeking behavior, and the inhibition may involve the modulation of dopaminergic activity.

Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference

It is concluded that gabapentin-like compounds, which have no intrinsic rewarding properties, may have some therapeutic use in the treatment of opioid dependence.

The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward

The data confirm previous results demonstrating that HDC KO mice show reduced exploratory behaviors, but contrary to the hypothesis that histamine plays an inhibitory role in reward, histamine-deficient mice were not more responsive to the psychostimulant effects of cocaine.