Carnosine ameliorates morphine-induced conditioned place preference in rats

@article{Gong2007CarnosineAM,
  title={Carnosine ameliorates morphine-induced conditioned place preference in rats},
  author={Ying-xia Gong and Hui-juan Wang and Yong-ping Zhu and Wei-Ping Zhang and Haibin Dai and Shihong Zhang and Er-qing Wei and Zhong Chen},
  journal={Neuroscience Letters},
  year={2007},
  volume={422},
  pages={34-38}
}
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CAR, ARG, and, importantly, their combination could effectively protect against hypoxia-induced neurotoxicity, via their angiogenic, anti-inflammatory, and anti-apoptotic properties in addition to reversing the effect on GABA and monoamines.

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Effects of carnosine on long-term plasticity of medial perforant pathway/dentate gyrus synapses in urethane-anesthetized rats: an in vivo model

The present experiment provides the first evidence that carnosine may play a role in synaptic plasticity in dentate gyrus in vivo and decreases LTP by inhibiting sGC activation.

Involvement of the brain histaminergic system in addiction and addiction-related behaviors: A comprehensive review with emphasis on the potential therapeutic use of histaminergic compounds in drug dependence

Endogenous opiates and behavior: 2007

L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: A double-blind, randomized placebo-controlled trial

References

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Endogenous histamine inhibits the development of morphine-induced conditioned place preference

Results indicate that endogenous histamine plays a role in inhibiting the development of morphine-induced reward-seeking behavior, and the inhibition may involve the modulation of dopaminergic activity.

Effects of carnosine on amygdaloid-kindled seizures in Sprague–Dawley rats

Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat

Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors.

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