Carnosine Release from Olfactory Bulb Synaptosomes Is Calcium‐Dependent and Depolarization‐Stimulated

@article{Rochel1982CarnosineRF,
  title={Carnosine Release from Olfactory Bulb Synaptosomes Is Calcium‐Dependent and Depolarization‐Stimulated},
  author={S Rochel and Frank L. Margolis},
  journal={Journal of Neurochemistry},
  year={1982},
  volume={38}
}
Abstract: The dipeptide carnosine (β‐alanyl‐L‐histidine) has been proposed as a neurotransmitter in the mammalian olfactory pathway. Therefore, the efflux of in vivo‐synthesized [14C]carnosine from mouse olfactory bulb synaptosomes was investigated. Carnosine was found to be released from the olfactory bulb synaptosomes by two mechanisms. The first is a slow spontaneous process that is independent of depolarization. The rate of this release was doubled in the presence of 1 mM external carnosine… 

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The Role of Endogenous Peptides in the Development of Long-Term Posttetanic Potentiation

  • A. A. Mokrushin
  • Biology
    Biology Bulletin of the Russian Academy of Sciences
  • 2004
It is proposed that two peptide pools are involved in the initial and late phases of LTP, and it has been demonstrated that the key target of these peptides are N-methyl-D-aspartate glutamate receptors.
...

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