Carnosine Release from Olfactory Bulb Synaptosomes Is Calcium‐Dependent and Depolarization‐Stimulated

  title={Carnosine Release from Olfactory Bulb Synaptosomes Is Calcium‐Dependent and Depolarization‐Stimulated},
  author={S Rochel and Frank L. Margolis},
  journal={Journal of Neurochemistry},
Abstract: The dipeptide carnosine (β‐alanyl‐L‐histidine) has been proposed as a neurotransmitter in the mammalian olfactory pathway. Therefore, the efflux of in vivo‐synthesized [14C]carnosine from mouse olfactory bulb synaptosomes was investigated. Carnosine was found to be released from the olfactory bulb synaptosomes by two mechanisms. The first is a slow spontaneous process that is independent of depolarization. The rate of this release was doubled in the presence of 1 mM external carnosine… 

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  • A. A. Mokrushin
  • Biology
    Biology Bulletin of the Russian Academy of Sciences
  • 2004
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