Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia.

@article{Yanagitai2012CarnosicAA,
  title={Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia.},
  author={Mika Yanagitai and Sayaka Itoh and Tomomi Kitagawa and Takato Takenouchi and Hiroshi Kitani and Takumi Satoh},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={418 1},
  pages={22-6}
}
In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 protein by the "electrophilic"quinone-type CA. Here, we found that the pro-electrophilic CA inhibited the in vitro lipopolysaccharide (LPS)-induced activation of cells of the mouse microglial cell line MG6. LPS induced the expression of IL-1β and IL-6, typical inflammatory cytokines… CONTINUE READING

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