Carnitine reduces testicular damage in rats treated with etoposide in the prepubertal phase

  title={Carnitine reduces testicular damage in rats treated with etoposide in the prepubertal phase},
  author={Fatima Kazue Okada and Taiza Stumpp and Sandra Maria Miraglia},
  journal={Cell and Tissue Research},
Etoposide is a chemotherapeutic agent that induces cell death by blocking topoisomerase II catalytic function. Although etoposide is effective in the treatment of cancer, it also causes the death of normal proliferating cells, including male germ cells. Administration of etoposide during the prepubertal phase causes diturbances in several testicular morphometric parameters and in Sertoli cells. Cytoprotection of the seminiferous epithelium is the only means of preserving potential male… 

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Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre‐puberty

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Sertoli cells showed morphological alterations such as the presence of chromatin clumps close to the nuclear membrane, nucleus displacement, and cytoplasmic vacuolization, suggesting that etoposide causes severe damages to Sertoli cell.

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