Carnitine reduces testicular damage in rats treated with etoposide in the prepubertal phase

@article{Okada2009CarnitineRT,
  title={Carnitine reduces testicular damage in rats treated with etoposide in the prepubertal phase},
  author={Fatima Kazue Okada and Taiza Stumpp and Sandra Maria Miraglia},
  journal={Cell and Tissue Research},
  year={2009},
  volume={337},
  pages={269-280}
}
Etoposide is a chemotherapeutic agent that induces cell death by blocking topoisomerase II catalytic function. Although etoposide is effective in the treatment of cancer, it also causes the death of normal proliferating cells, including male germ cells. Administration of etoposide during the prepubertal phase causes diturbances in several testicular morphometric parameters and in Sertoli cells. Cytoprotection of the seminiferous epithelium is the only means of preserving potential male… 
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Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal rats

Data show that doxorubicin administration during prepuberty causes functional and morphological late damage to Sertoli cells; such damage is secondary to the germ cell primary injury and contributed to enhance the spermatogenic harm caused by this drug.

Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre‐puberty

Carnitine reduced the late testicular and spermatic damages caused by doxorubicin, probably providing a partial cytoprotection against the deleterious action of doxorbicin administration to pre‐pubertal rats.

L-carnitine counteracts prepubertal exposure to cisplatin induced impaired sperm in adult rats by preventing germ cell apoptosis

L-carnitine may reduce late testicular and spermatic damage caused by cisplatin administration to prepubertal rats by inducing germ cell proliferation and preventing apoptosis and during the adult period, epididymal sperm count and viability were improved in rats treated with L-c Carnage.

Long-term testicular toxicity caused by doxorubicin treatment during pre-pubertal phase

The administration of doxorubicin during early prepubertal age can lead to severe injury of the adult fertility, and this drug causes apoptosis of male germ cells.

Use of antioxidant could ameliorate the negative impact of etoposide on human sperm DNA during chemotherapy.

Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin‐treated rats

Doxorubicin has been largely used in anticancer therapy in adults, adolescents, and children. The efficacy of l‐carnitine as an antioxidant substance has been confirmed both in humans and rats.…

How does chemotherapy treatment damage the prepubertal testis?

Understanding of how chemotherapy agents target the prepubertal testis will provide clarity to patients on the gonadotoxicity of different drugs and aid in the development of cytoprotective agents.

Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase

The results showed that the preventive use of L-carnitine can reduce the testicular deleterious effects caused by vincristine sulfate, since variables such as absolute testicular weight, relative testicle weight, and testicular minor axis indicated the mitigation of damages resulting from the action of the antineoplastic, mainly in acute and subacute phases.

Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide

The results indicate that NAC has the ability to counteract etoposide-induced toxicity rather than preventing the etopOSide cytotoxic effects over sperm DNA, suggesting that the administration of NAC to cells formerly exposed to etOPoside is preferable to its prophylactic use.

Carnitine Diminishes Etoposide Toxic Action on Spermatogonial Self-renewal and Sperm Production in Adult Rats Treated in the Prepubertal Phase

It is suggested that carnitine improves the self-renewal of undifferentiated spermatogonia and promotes a partial protection on them, alleviating the etoposide harmful late effects and leading to an enhancement of the sperm parameters in adulthood.

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