Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre‐puberty

@article{Cabral2014CarnitinePP,
  title={Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre‐puberty},
  author={R E L Cabral and Fatima Kazue Okada and Taiza Stumpp and Vanessa Vendramini and Sandra Maria Miraglia},
  journal={Andrology},
  year={2014},
  volume={2}
}
Doxorubicin, an anticancer drug, is widely included in chemotherapy protocols to combat childhood cancer. Carnitine, an important quaternary amine, is present in testis and epididymis and is involved in sperm maturation; it has been used in infertility treatment. In a previous study, our group observed that l‐carnitine given before etoposide, another chemotherapeutic drug, reduces the spermatogenic damage and protects germ cells against apoptosis. This study aimed to evaluate the antiapoptotic… 

Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin‐treated rats

Doxorubicin has been largely used in anticancer therapy in adults, adolescents, and children. The efficacy of l‐carnitine as an antioxidant substance has been confirmed both in humans and rats.

L-carnitine counteracts prepubertal exposure to cisplatin induced impaired sperm in adult rats by preventing germ cell apoptosis

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The following morphological, physiological, and biochemical alterations were observed due to chronic exposure of copper to rats in comparison with the untreated control: generation of oxidative stress through rise in testis lipid peroxidation, severe damage of spermatogonia and Sertoli cells.

Cancer Induced Infertility and the Role of L-Carnitine: A Review for Possible Future Clinical Applications

According to animal studies, the administration of LC could show a promising protective data, but before any judgment, further large controlled studies are required and issue is matter of concern in future studies.

Ameliorative effects of l-carnitine on rats raised on a diet supplemented with lead acetate

Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase

The results showed that the preventive use of L-carnitine can reduce the testicular deleterious effects caused by vincristine sulfate, since variables such as absolute testicular weight, relative testicle weight, and testicular minor axis indicated the mitigation of damages resulting from the action of the antineoplastic, mainly in acute and subacute phases.

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