Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre‐puberty

  title={Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre‐puberty},
  author={R E L Cabral and Fatima Kazue Okada and Taiza Stumpp and Vanessa Vendramini and Sandra Maria Miraglia},
Doxorubicin, an anticancer drug, is widely included in chemotherapy protocols to combat childhood cancer. Carnitine, an important quaternary amine, is present in testis and epididymis and is involved in sperm maturation; it has been used in infertility treatment. In a previous study, our group observed that l‐carnitine given before etoposide, another chemotherapeutic drug, reduces the spermatogenic damage and protects germ cells against apoptosis. This study aimed to evaluate the antiapoptotic… 

Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin‐treated rats

Doxorubicin has been largely used in anticancer therapy in adults, adolescents, and children. The efficacy of l‐carnitine as an antioxidant substance has been confirmed both in humans and rats.

L-carnitine counteracts prepubertal exposure to cisplatin induced impaired sperm in adult rats by preventing germ cell apoptosis

L-carnitine may reduce late testicular and spermatic damage caused by cisplatin administration to prepubertal rats by inducing germ cell proliferation and preventing apoptosis and during the adult period, epididymal sperm count and viability were improved in rats treated with L-c Carnage.

Carnitine Diminishes Etoposide Toxic Action on Spermatogonial Self-renewal and Sperm Production in Adult Rats Treated in the Prepubertal Phase

It is suggested that carnitine improves the self-renewal of undifferentiated spermatogonia and promotes a partial protection on them, alleviating the etoposide harmful late effects and leading to an enhancement of the sperm parameters in adulthood.

How does chemotherapy treatment damage the prepubertal testis?

Understanding of how chemotherapy agents target the prepubertal testis will provide clarity to patients on the gonadotoxicity of different drugs and aid in the development of cytoprotective agents.

Testicular toxicity and sperm quality following copper exposure in Wistar albino rats: ameliorative potentials of L-carnitine

The following morphological, physiological, and biochemical alterations were observed due to chronic exposure of copper to rats in comparison with the untreated control: generation of oxidative stress through rise in testis lipid peroxidation, severe damage of spermatogonia and Sertoli cells.

Cancer Induced Infertility and the Role of L-Carnitine: A Review for Possible Future Clinical Applications

According to animal studies, the administration of LC could show a promising protective data, but before any judgment, further large controlled studies are required and issue is matter of concern in future studies.

Ameliorative effects of l-carnitine on rats raised on a diet supplemented with lead acetate

Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase

The results showed that the preventive use of L-carnitine can reduce the testicular deleterious effects caused by vincristine sulfate, since variables such as absolute testicular weight, relative testicle weight, and testicular minor axis indicated the mitigation of damages resulting from the action of the antineoplastic, mainly in acute and subacute phases.



Amifostine Protective Effect on Cisplatin‐Treated Rat Testis

It is concluded that the amifostine previously administered to prepubertal rats reduced the testicular damage caused by cisplatin, and partially protected the rat seminiferous epithelium against cisPlatin toxicity.

Carnitine reduces testicular damage in rats treated with etoposide in the prepubertal phase

Carnitine is investigated to suggest that carnitine partially protects the testis against damage caused by etoposide, although the mechanism by which it happens remains unknown.

Amifostine reduces the seminiferous epithelium damage in doxorubicin-treated prepubertal rats without improving the fertility status

It is suggested that amifostine promotes a significant reduction of the doxorubicin long-term side effects on the seminiferous epithelium of prepubertal rats, which is reflected in the epidydimal fluid parameters in the adult phase, however, fertility status results suggest that such protection may not be effective against sperm DNA content damage.

Antiapoptotic effect of l-carnitine on testicular irradiation in rats

It is suggested that l-carnitine supplementation during the radiotherapy may be beneficial for spermatogenesis following testicular irradiation by decreasing germ cell apoptosis.

Cadmium Toxicity in Spermatogenesis and Protective Effects of l-Carnitine in Adult Male Rats

L-carnitine treatment caused an increase in the number and viability of cauda epididymis sperm, the number of cell proliferation, and Johnsen Scores in the cadmium-induced group.

Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal rats

Data show that doxorubicin administration during prepuberty causes functional and morphological late damage to Sertoli cells; such damage is secondary to the germ cell primary injury and contributed to enhance the spermatogenic harm caused by this drug.

Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest.

Amifostine-doxorubicin-exposed rat spermatogonia produced long-term damage on sperm DNA, compromised conceptus development and reduced pregnancy outcome, raising a concern about the effects of the association of these two drugs on the germ cell genome.

Doxorubicin Toxicity can be Ameliorated during Antioxidant L-Carnitine Supplementation

It is suggested that the reduction of antioxidant defense during doxorubicin administration resulted in hepatic injury could be prevented by L-carnitine supplementation by decreasing the oxidative stress and preserving both the activity and gene expression level of antioxidant enzymes.

L‐carnitine prevents doxorubicin‐induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation

Findings show that by inhibiting a (perhaps novel) drug‐activated acid sphingomyelinase and ceramide generation, L‐carnitine can prevent doxorubicin‐induced apoptosis of cardiac myocytes.

Role of l-carnitine in the prevention of seminiferous tubules damage induced by gamma radiation: a light and electron microscopic study

L-carnitine supplementation during the radiotherapy would be effective in protecting against radiation-induced damages in rat testis, and thereby may improve the quality of patient’s life after the therapy.