Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity.

@article{He2012CarnitinePD,
  title={Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity.},
  author={Lan He and Teayoun Kim and Qinqiang Long and Jian Liu and Peiyong Wang and Yiqun Zhou and Yishu Ding and J K Prasain and Philip A. Wood and Qinglin Yang},
  journal={Circulation},
  year={2012},
  volume={126 14},
  pages={1705-16}
}
BACKGROUND Carnitine palmitoyltransferase-1 (CPT1) is a rate-limiting step of mitochondrial β-oxidation by controlling the mitochondrial uptake of long-chain acyl-CoAs. The muscle isoform, CPT1b, is the predominant isoform expressed in the heart. It has been suggested that inhibiting CPT1 activity by specific CPT1 inhibitors exerts protective effects against cardiac hypertrophy and heart failure. However, clinical and animal studies have shown mixed results, thereby creating concerns about the… CONTINUE READING