Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux.

@article{Eaton2001CarnitinePT,
  title={Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux.},
  author={Simon Eaton and Kenta Fukumoto and N Paladio Duran and Agostino Pierro and L. Spitz and Patti A. Quant and Kim Bartlett},
  journal={Biochemical Society transactions},
  year={2001},
  volume={29 Pt 2},
  pages={245-50}
}
Carnitine palmitoyltransferase I is assumed to be rate limiting for beta-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit beta-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase… CONTINUE READING

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