Carnitine metabolism in early stages of Duchenne muscular dystrophy.

  title={Carnitine metabolism in early stages of Duchenne muscular dystrophy.},
  author={Gis{\`e}le Berthillier and Denise Eichenberger and Henri Carrier and Pierre Guibaud and Ren{\'e} Got},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={122 3},
Muscle carnitine deficiency was found in 12 children affected with Duchenne muscular dystrophy (DMD), the diagnosis being made at a preclinical stage or at the beginning of the clinical symptoms. Enzymatic activities related to fatty acid transport and carnitine metabolism were studied in these patients and normal subjects: palmitoyl carnitine transferase was increased, palmitoyl carnitine hydrolase was not found in the muscle, palmitoyl coenzyme A synthetase was normal and palmitoyl coenzyme A… CONTINUE READING