Carnitine inhibits arachidonic acid turnover, platelet function, and oxidative stress.

  title={Carnitine inhibits arachidonic acid turnover, platelet function, and oxidative stress.},
  author={Pasquale Pignatelli and Luisa Lenti and Valerio Sanguigni and Giacomo Frati and Iuliana Simeoni and Pier Paolo Gazzaniga and Fabio M. Pulcinelli and Francesco Violi},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={284 1},
  • P. PignatelliL. Lenti F. Violi
  • Published 2003
  • Biology, Medicine, Computer Science
  • American journal of physiology. Heart and circulatory physiology
Carnitine is a physiological cellular constituent that favors intracellular fatty acid transport, whose role on platelet function and O(2) free radicals has not been fully investigated. The aim of this study was to seek whether carnitine interferes with arachidonic acid metabolism and platelet function. Carnitine (10-50 microM) was able to dose dependently inhibit arachidonic acid incorporation into platelet phospholipids and agonist-induced arachidonic acid release. Incubation of platelets… 

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