Carnitine depletion in rat pups from mothers given mildronate: a model of carnitine deficiency in late fetal and neonatal life.

@article{Peschechera2005CarnitineDI,
  title={Carnitine depletion in rat pups from mothers given mildronate: a model of carnitine deficiency in late fetal and neonatal life.},
  author={Alessandro Peschechera and Maurizio Scalibastri and Francesco Russo and Mauro Giorgio Giarrizzo and Paolo Carminati and Fabio Giannessi and Arduino Arduini and Rita Ricciolini},
  journal={Life sciences},
  year={2005},
  volume={77 24},
  pages={3078-91}
}
Mildronate (3-(2,2,2,-trimethylhydrazinium)propionate), is a butyrobetaine analogue that is known to inhibit gamma-butyrobetaine hydroxylase, the enzyme catalyzing the last step of carnitine biosynthesis. When administered to adult rats it determines a systemic carnitine deficiency and may therefore serve as an animal model for human carnitine depletion. The aim of this study was to evaluate the effect of mildronate administration to pregnant and lactating rats on tissue carnitine… CONTINUE READING
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