Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats.

  title={Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats.},
  author={Abdulhakeem A. Al-Majed},
  journal={Basic \& clinical pharmacology \& toxicology},
  volume={100 3},
  • A. Al-Majed
  • Published 1 March 2007
  • Biology
  • Basic & clinical pharmacology & toxicology
This study investigates whether or not carnitine deficiency is a risk factor and could contribute to cisplatin-induced liver toxicity. A total of 60 adult male Wistar albino rats were divided into six groups. The first three groups were injected intraperitoneally with normal saline, propionyl-l-carnitine (500 mg/kg), and d-carnitine (500 mg/kg), respectively, for 10 successive days. The fourth, fifth and sixth groups were injected intraperitoneally with the same doses of normal saline… 

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Data from the present study suggest that PLC prevents the development of CDDP‐induced acute renal injury by a mechanism related, at least in part, to the ability of PLC to increase intracellular carnitine content, with a consequent improvement in mitochondrial oxidative phosphorylation and energy production, as well as its ability to decrease oxidative stress.

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  • 2010
Interestingly, l-carnitine supplementation resulted in a complete reversal of the increase in serum creatinine, BUN, urinary carnitine excretion and the decrease in total Carnivalitine, intramitochondrial CoA-SH and ATP, induced by GM, to the control values.

Dose-dependent protective effect of L-carnitine on oxidative stress in the livers of hyperthyroid rats.

Treating hyperthyroid rats with both low-dose and high-dose L-carnitine for 10 days resulted in a marked increase in the activities of the antioxidant enzymes in the liver tissue.

The Effect of L-Carnitine on Oxidative Stress Responses of Experimental Contrast-Induced Nephropathy in Rats

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Carnitine deficiency: a possible risk factor in paracetamol hepatotoxicity

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Protective Effect of Ginger Extract Against Cisplatin-Induced Hepatotoxicity and Cardiotoxicity in Rats.

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Progression of Cisplatin-Induced Nephrotoxicity in a Carnitine-Depleted Rat Model

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Effect of spironolactone on cisplatininduced nephrotoxicity in rabbits

Spironolactone aggravates the cisplatin-induced nephrotoxicity in the rabbit and causes accumulation of cholesterol and TAG in the kidney cortex with significant depletion of the liver cholesterol content.

Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats.

Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats

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Morphological and histochemical evidence of the protective effect of procainamide hydrochloride on tissue damage induced by repeated administration of low doses of cisplatin.

The morphological and histochemical data confirm that procainamide hydrochloride is able to protect not only from acute cisplatin-induced toxicities, but also from tissue alterations induced in the liver and kidneys by the administration of repeated low doses of cisPlatin.

Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1.

  • Yongke LuA. Cederbaum
  • Biology, Chemistry
    Toxicological sciences : an official journal of the Society of Toxicology
  • 2006
Results indicate that elevated CYP2E1 enhances cisplatin-induced hepatotoxicity, and the mechanism may involve increased production of ROS and oxidative stress.