Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats.

@article{AlMajed2007CarnitineDP,
  title={Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats.},
  author={Abdulhakeem A. Al-Majed},
  journal={Basic \& clinical pharmacology \& toxicology},
  year={2007},
  volume={100 3},
  pages={
          145-50
        }
}
  • A. Al-Majed
  • Published 1 March 2007
  • Biology
  • Basic & clinical pharmacology & toxicology
This study investigates whether or not carnitine deficiency is a risk factor and could contribute to cisplatin-induced liver toxicity. A total of 60 adult male Wistar albino rats were divided into six groups. The first three groups were injected intraperitoneally with normal saline, propionyl-l-carnitine (500 mg/kg), and d-carnitine (500 mg/kg), respectively, for 10 successive days. The fourth, fifth and sixth groups were injected intraperitoneally with the same doses of normal saline… 

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