Carnitine deficiency-induced cardiomyopathy

  title={Carnitine deficiency-induced cardiomyopathy},
  author={Dennis J. Paulson},
  journal={Molecular and Cellular Biochemistry},
The results of clinical and animal studies suggest that a short term period of moderate secondary carnitine deficiency, in and of itself, does not have a major effect on the cardiac contractile function, although substrate oxidation may be altered. However, with longer durations of carnitine deficiency, alterations occur within the heart that may result in impaired contractile performance, particularly at high workloads. At this point, the mechanisms responsible for the cardiac depression are… CONTINUE READING


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Carnitine disorders

  • CA Stanley
  • Adv Pediatr
  • 1995

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