Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.

@article{Kwok2006CarnitinexenobioticsTI,
  title={Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.},
  author={Bruce Kwok and Ariko Yamauchi and Ratheishan Rajesan and Lillian Chan and Upinder S. Dhillon and Wen Gao and Haibo Xu and Bernice Wang and Shin-ichiro Takahashi and John Semple and Ikumi Tamai and Jun-ichi Nezu and Akira Tsuji and Patricia Harper and Shinya Ito},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2006},
  volume={290 3},
  pages={
          R793-802
        }
}
The barrier function of the human mammary gland collapses if challenged with cationic drugs, causing their accumulation in milk. However, underlying molecular mechanisms are not well understood. To gain insight into the mechanism, we characterized transport of organic cations in the MCF12A human mammary gland epithelial cells, using carnitine and tetraethylammonium (TEA) as representative nutrient and xenobiotics probes, respectively. Our results show that the mammary gland cells express mRNA… CONTINUE READING

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