Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.

  title={Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.},
  author={Bruce Kwok and Ariko Yamauchi and Ratheishan Rajesan and Lillian Chan and Upinder Dhillon and Wen Gao and Haibo Xu and Bernice Wang and Shinichirou Takahashi and John L Semple and Ikumi Tamai and Junichi Nezu and Akira Tsuji and Patricia A. Harper and Shinya Ito},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={290 3},
  • Bruce KwokAriko Yamauchi S. Ito
  • Published 1 March 2006
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
The barrier function of the human mammary gland collapses if challenged with cationic drugs, causing their accumulation in milk. However, underlying molecular mechanisms are not well understood. To gain insight into the mechanism, we characterized transport of organic cations in the MCF12A human mammary gland epithelial cells, using carnitine and tetraethylammonium (TEA) as representative nutrient and xenobiotics probes, respectively. Our results show that the mammary gland cells express mRNA… 

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  • I. Tamai
  • Biology, Medicine
    Biopharmaceutics & drug disposition
  • 2013
The carnitine/organic cation transporter (OCTN) family consists of three transporter isoforms, i.e. OCTN1 and OCTN2 in humans and animals and Octn3 (Slc22a21) in mice, which are physiologically, pathologically and pharmacologically important.

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