Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.

@article{Kwok2006CarnitinexenobioticsTI,
  title={Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.},
  author={Bruce Kwok and Ariko Yamauchi and Ratheishan Rajesan and Lillian Chan and Upinder Dhillon and Wen Gao and Haibo Xu and Bernice Wang and Shinichirou Takahashi and John L Semple and Ikumi Tamai and Junichi Nezu and Akira Tsuji and Patricia A. Harper and Shinya Ito},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2006},
  volume={290 3},
  pages={
          R793-802
        }
}
  • Bruce KwokAriko Yamauchi S. Ito
  • Published 1 March 2006
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
The barrier function of the human mammary gland collapses if challenged with cationic drugs, causing their accumulation in milk. However, underlying molecular mechanisms are not well understood. To gain insight into the mechanism, we characterized transport of organic cations in the MCF12A human mammary gland epithelial cells, using carnitine and tetraethylammonium (TEA) as representative nutrient and xenobiotics probes, respectively. Our results show that the mammary gland cells express mRNA… 

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ABC- and SLC-Transporters in Murine and Bovine Mammary Epithelium - Effects of Prochloraz

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Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk

Transporters overexpressed during lactation are focused on and their role in the transfer of products into the milk, including both beneficial and harmful compounds are described.

Transport of L-carnitine in human corneal and conjunctival epithelial cells

L-carnitine is transported into HCLE and HCjE cells by an active carrier mediated transport system that is time-, Na+-, energy- and pH- dependent.

Acute administration of cefepime lowers L-carnitine concentrations in early lactation stage rat milk.

Cefepime significantly decreased milk L-carnitine concentrations only at d 4 of lactation, and enhanced expression of OCTN2 and ATB(0,+) in mammary glands at d4 of lactATION and higher M/S suggests cefepimes competes with L- c Carnitine for L-Carn itine transporters expressed in the lactating mammary gland to adversely affect L-barnitines milk concentrations.

Transport Proteins in Mammary Epithelial Cells Studies in Murine ( HC 11 ) and Bovine ( BME-UV ) Cells – Effects of Prochloraz

The HC11 and BME-UV mammary cell models are valuable tools for identifying substrates, inhibitors and inducers of transport proteins expressed in the mammary epithelium during lactation and can be used both to examine if chemical compounds are actively transported into milk and if they disrupt the normal function of transporters which may result in a disturbed delivery of essential nutrients into milk.

Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21).

  • I. Tamai
  • Biology, Medicine
    Biopharmaceutics & drug disposition
  • 2013
The carnitine/organic cation transporter (OCTN) family consists of three transporter isoforms, i.e. OCTN1 and OCTN2 in humans and animals and Octn3 (Slc22a21) in mice, which are physiologically, pathologically and pharmacologically important.

Title Pharmacological and pathophysiological roles of carnitine / organic cationtransporters ( OCTNs : SLC 22 A 4 , SLC 22 A 5 and Slc 22 a 21 ) Author ( s

The carnitine/organic cation transporter (OCTN) family consists of three transporter isoforms, i.e., OCTN1 and OCTN2 in humans and animals and Octn3 (Slc22a21) in mice, which are physiologically, pathologically and pharmacologically important.

The Carnitine Transporter Network: Interactions with Drugs

The current knowledge of the characterization of the carnitine transporter network and the interaction with drugs are reviewed with emphasis to the most recent data obtained using the proteoliposome reconstituted systems.

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