Caries vaccine: A boom for public health

  title={Caries vaccine: A boom for public health},
  author={Richie Chhabra and Karan Rajpal},
  journal={Annals of Tropical Medicine and Public Health},
  pages={1 - 3}
Dental caries is one of the most common irreversible diseases of the tooth structure where a wide group of microorganisms are responsible as they are the main etiologic bacteria. To reduce the incidence and prevalence of dental caries, various modalities have been adopted over the years by modifying various etiologic factors. One of the latest advances is caries vaccine that involves the application of advanced genetic technique by modifying Streptococcus mutans (S. mutans) and using it as a… 
Caries vaccine: A narrative review
The aim of the present narrative review is to discuss various aspects of the dental caries vaccine.
La caries dental es una enfermedad que predomina en la poblacion mundial y que afecta especialmente a los ninos. El presente articulo busca mostrar las tecnicas de prevencion actuales a traves de una
Nanoparticulate systems for dental drug delivery
  • M. Koopaie
  • Biology, Materials Science
    Nanoengineered Biomaterials for Advanced Drug Delivery
  • 2020
Production of hyperimmune colostrum in the bovine against cariogenic streptococci and assess its impact on growth and biofilm formation of bacteria
It is shown here how to identify the different types of phytochemical reactions in the blood of a person bitten by a venomous snake.
Evaluation of hyperimmune colostrum production in bovine against cariogenic streptococci and its impact on growth and bacterial biofilm formation
According to the antibacterial effect immune colostrum on two strains of cariogenic bacteria in vitro, It appears that this material could be useful in the prevention and control of dental caries.


Dental caries vaccine.
Dental caries is an infectious microbiologic disease of the teeth that results in localized dissolution and destruction of the calcified tissue, which is caused by host, agent, and environmental factors.
Dental caries is a preventable infectious disease.
What is currently known about these ubiquitous pathogens Streptococcal species collectively referred to as the mutans streptococci and novel methods for elimination of these bacteria from dental plaque are outlined.
Dental caries vaccine - a possible option?
Clinical trials have indicated that a mucosal immune response to Streptococcus mutans crucial antigens can influence the pathogenesis of dental carie, and the dental caries vaccine, when it is used in appropriate individuals at the appropriate time, can reduce the reemergence of the disease.
Caries vaccines for the twenty-first century.
The caries-protective capacity of active immunization with dental caries vaccines now awaits proof of principle in pediatric clinical trials.
A paradigm shift in the treatment of caries.
A shift in the paradigm for treating dental caries is presented from a surgical to a medical approach consisting of four steps: bacterial control; reduction of risk levels for at-risk patients; reversal of active sites by remineralization; and follow-up and maintenance.
Immunologic Basis for Vaccination Against Dental Caries in Rhesus Monkeys
The effects of immunization with Streptococcus mutans on the development of caries and the immune responses were investigated in 37 young rhesus monkeys (Macaca mulatta) during a period of up to 33
Nanodrug delivery systems in dentistry: a review on current status and future perspectives.
Dentistry should follow the trend of probing matter at nanoscale to achieve a predictable treatment outcome, and identify few dental applications demanding extensive research to emerge as a promising therapeutic strategy.
Natural History of Streptococcus sanguinis in the Oral Cavity of Infants: Evidence for a Discrete Window of Infectivity
It is found that the colonization of S. sanguinis occurs during a discrete “window of infectivity” at a median age of 9 months in the infants, and this in turn may suggest several ecological approaches toward controlling dental caries.
Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface.
It is demonstrated that the host salivary protein CSP-1 binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface.
Oral immunization of humans with Streptococcus sobrinus glucosyltransferase
The data indicate that oral administration of GTF from the mutans streptococci has the potential to elicit a salivary IgA antibody response when combined with an aluminum-based adjuvant and that this response can interfere with the reaccumulation of indigenous S. mutans following dental prophylaxis.