Caribbean maitotoxin elevates [Ca(2+)]i and activates non-selective cation channels in HIT-T15 cells.

Abstract

AIM To investigate the cytotoxic mechanism of caribbean maitotoxin (MTX-C) in mammalian cells. METHODS We used whole-cell patch-clamp techniques and fluorescence calcium imaging to determine the cellular toxic mechanisms of MTX-C in insulin secreting HIT-T15 cells, which is a system where the effects of MTX have been observed. HIT-T15 cells stably express… (More)
DOI: 10.4239/wjd.v4.i3.70

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@article{Lu2013CaribbeanME, title={Caribbean maitotoxin elevates [Ca(2+)]i and activates non-selective cation channels in HIT-T15 cells.}, author={Xin-Zhong Lu and Robert Deckey and Guo-liang Jiao and Hui-feng Ren and Ming Li}, journal={World journal of diabetes}, year={2013}, volume={4 3}, pages={70-5} }