Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

  title={Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing},
  author={Dinari A. Harris and Kevin Kim and Kenji Nakahara and Constanza V{\'a}squez-Doorman and Richard W. Carthew},
  booktitle={The Journal of cell biology},
Mammals lacking BLOC-3 have impaired formation of melanosomes, a type of lysosome-related organelle (LRO), and, in earlier work, we found that a subunit of the BLOC-3 complex inhibits loading of Argonaute (Ago) proteins with small ribonucleic acids (RNAs) in Drosophila melanogaster cells. Small RNAs such as small interfering RNAs (siRNAs) direct Ago proteins to repress the stability of messenger RNA transcripts. In this paper, we show that BLOC-3 is required for biogenesis of Drosophila LROs… CONTINUE READING
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