Cargo selection into COPII vesicles is driven by the Sec24p subunit.

@article{Miller2002CargoSI,
  title={Cargo selection into COPII vesicles is driven by the Sec24p subunit.},
  author={Elizabeth A Miller and Bruno Antonny and Susan T. Hamamoto and Randy Schekman},
  journal={The EMBO journal},
  year={2002},
  volume={21 22},
  pages={6105-13}
}
Transport of secretory proteins out of the endoplasmic reticulum (ER) is mediated by vesicles generated by the COPII coat complex. In order to understand how cargo molecules are selected by this cytoplasmic coat, we investigated the functional role of the Sec24p homolog, Lst1p. We show that Lst1p can function as a COPII subunit independently of Sec24p on native ER membranes and on synthetic liposomes. However, vesicles generated with Lst1p in the absence of Sec24p are deficient in a distinct… CONTINUE READING

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