Cargo binding induces dimerization of myosin VI.

@article{Phichith2009CargoBI,
  title={Cargo binding induces dimerization of myosin VI.},
  author={Denis Phichith and Mirko Travaglia and Zhaohui Yang and Xiaoyan Liu and Alan B. Zong and Daniel Safer and H Lee Sweeney},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 41},
  pages={
          17320-4
        }
}
Although myosin VI has properties that would allow it to function optimally as a dimer, full-length myosin VI exists as a monomer in isolation. Based on the ability of myosin VI monomers to dimerize when held in close proximity, we postulated that cargo binding normally regulates dimerization of myosin VI. We tested this hypothesis by expressing a known dimeric cargo adaptor protein of myosin VI, optineurin, and the myosin VI-binding segment from a monomeric cargo adaptor protein, Dab2. In the… CONTINUE READING

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