Caretaker tumour suppressor genes that defend genome integrity.

@article{Levitt2002CaretakerTS,
  title={Caretaker tumour suppressor genes that defend genome integrity.},
  author={Nicola C Levitt and Ian D. Hickson},
  journal={Trends in molecular medicine},
  year={2002},
  volume={8 4},
  pages={179-86}
}
Cancers arise as a result of genetic changes that impact upon cell proliferation through promoting cell division and/or inhibiting cell death. Tumour suppressor (TS) genes are the targets for many of these genetic changes. In general, both alleles of TS genes must be disrupted to observe a phenotypic effect. Broadly speaking, there are two types of TS gene: 'gatekeepers' and 'caretakers'. In contrast to gatekeepers, caretaker genes do not directly regulate proliferation, but act to prevent… CONTINUE READING

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