Caretaker tumour suppressor genes that defend genome integrity.

  title={Caretaker tumour suppressor genes that defend genome integrity.},
  author={Nicola C Levitt and Ian D. Hickson},
  journal={Trends in molecular medicine},
  volume={8 4},
Cancers arise as a result of genetic changes that impact upon cell proliferation through promoting cell division and/or inhibiting cell death. Tumour suppressor (TS) genes are the targets for many of these genetic changes. In general, both alleles of TS genes must be disrupted to observe a phenotypic effect. Broadly speaking, there are two types of TS gene: 'gatekeepers' and 'caretakers'. In contrast to gatekeepers, caretaker genes do not directly regulate proliferation, but act to prevent… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 46 extracted citations

Similar Papers

Loading similar papers…