Caretaker or undertaker? The role of the proteasome in aging.

Abstract

Despite intensive studies, the molecular basis of the decline of protein degradation with age still remains unresolved. It is suspected that the proteasome is one of the key factors controlling the age-dependent turnover of intracellular proteins. This hypothesis is based on the observation that the proteasome is a part of the ubiquitin-proteasome pathway… (More)

Cite this paper

@article{Gaczynska2001CaretakerOU, title={Caretaker or undertaker? The role of the proteasome in aging.}, author={Maria E. Gaczynska and Pawel A. Osmulski and William F. Ward}, journal={Mechanisms of ageing and development}, year={2001}, volume={122 3}, pages={235-54} }