Cardiovascular safety of non-steroidal anti-inflammatory drugs revisited.

  title={Cardiovascular safety of non-steroidal anti-inflammatory drugs revisited.},
  author={Chris Walker and Luigi Marzio Biasucci},
  journal={Postgraduate medicine},
  volume={130 1},
Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used to treat inflammatory pain for decades. More recently, newer NSAIDs were developed to target the inducible isoform of cyclooxygenase (COX), COX-2, with the aim of reducing gastrointestinal toxicity. While the COX-2 selective inhibitors were effective in reducing pain and gastrointestinal harm, they soon were associated with an increased risk of adverse cardiovascular events. Initially, the view emerged that selective… CONTINUE READING
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