Cardiovascular risk factors impair native collateral development and may impair efficacy of therapeutic interventions.

@article{Kinnaird2008CardiovascularRF,
  title={Cardiovascular risk factors impair native collateral development and may impair efficacy of therapeutic interventions.},
  author={Timothy D Kinnaird and Eugenio Stabile and Stephan Zbinden and M S Burnett and Stephen E. Epstein},
  journal={Cardiovascular research},
  year={2008},
  volume={78 2},
  pages={257-64}
}
Animal and early clinical studies of gene therapy for tissue ischaemia suggested that this approach might provide benefit to patients with coronary artery disease not amenable to traditional revascularization. This enthusiasm was then tempered by the subsequent disappointing results of randomized clinical trials and led researchers to develop strategies using progenitor cells as an alternative to improve collateral function. However, the recent publication of several randomized clinical trials… CONTINUE READING

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