Cardiovascular risk factors and dementia mortality: 40 years of follow-up in the Seven Countries Study

  title={Cardiovascular risk factors and dementia mortality: 40 years of follow-up in the Seven Countries Study},
  author={{\'A}lvaro Alonso and David R. Jacobs and Alessandro Menotti and Aulikki Nissinen and Anastasios S. Dontas and Anthony G. Kafatos and Daan Kromhout},
  journal={Journal of the Neurological Sciences},

Midlife vascular risk factors and their association with dementia deaths: Results from a Norwegian prospective study followed up for 35years

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In people at increased CV risk, impairments on baseline cognitive testing are associated with a graded increase in the risk of stroke, congestive heart failure, and CV death, but not coronary events.

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People aged 60–69 years with near-ideal cardiovascular risk factor profiles have substantially lower incidence of geriatric conditions and frailty, and Optimizing cardiovascular disease risk factors may substantially reduce the burden of morbidity in later life.



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The z-score sum was higher in demented subjects than in nondemented subjects, indicating a higher risk factor burden, and clustering of metabolic cardiovascular risk factors increases the risk of dementia (mainly, dementia of vascular origin).

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Obesity at midlife is associated with an increased risk of dementia and AD later in life and the role of weight reduction for the prevention of dementia needs to be further investigated.

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A J-shaped relationship was observed between BMI and dementia, such that a BMI less than 20 and an increasing BMI of 22.5 or greater were associated with increased risk from midlife to old age of a primary hospital diagnosis of dementia.

Vascular Risk Factors for Incident Alzheimer Disease and Vascular Dementia: The Cache County Study

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Forty-year coronary mortality trends and changes in major risk factors in the first 10 years of follow-up in the seven countries study

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Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study.

Diabetes mellitus did not increase the risk of incident AD in the Framingham cohort overall; however, DM may be a risk factor forAD in the absence of other known major AD risk factors.