Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention.

@article{Solomon2005CardiovascularRA,
  title={Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention.},
  author={Scott Solomon and John J V McMurray and Marc Pfeffer and Janet Wittes and Robert Ludlow Fowler and Peter Finn and W. French Anderson and Ann Graham Zauber and Ernest T. Hawk and Monica M. Bertagnolli},
  journal={The New England journal of medicine},
  year={2005},
  volume={352 11},
  pages={
          1071-80
        }
}
BACKGROUND Selective cyclooxygenase-2 (COX-2) inhibitors have come under scrutiny because of reports suggesting an increased cardiovascular risk associated with their use. Experimental research suggesting that these drugs may contribute to a prothrombotic state provides support for this concern. METHODS We reviewed all potentially serious cardiovascular events among 2035 patients with a history of colorectal neoplasia who were enrolled in a trial comparing two doses of celecoxib (200 mg or… CONTINUE READING

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