Cardiovascular risk, metabolic profile, and body composition in adult males with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

@article{Falhammar2011CardiovascularRM,
  title={Cardiovascular risk, metabolic profile, and body composition in adult males with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.},
  author={Henrik Falhammar and Helena Filipsson Nystr{\"o}m and Anna Wedell and Marja Thor{\'e}n},
  journal={European journal of endocrinology},
  year={2011},
  volume={164 2},
  pages={
          285-93
        }
}
OBJECTIVE Lifelong glucocorticoid therapy in patients with congenital adrenal hyperplasia (CAH) or the disease per se may result in increased cardiovascular risk. We therefore investigated cardiovascular and metabolic risk profiles in adult CAH males. SUBJECTS AND METHODS We compared CAH males (n = 30), 19-67 years old, with age- and sex-matched controls (n = 32). Subgroups of different ages (< 30 years or older) and CYP21A2 genotypes (null, I2splice, and I172N as the mildest mutation) were… CONTINUE READING

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